Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QS4

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0009408	biological_process	response to heat
A	0016887	molecular_function	ATP hydrolysis activity
A	0034605	biological_process	cellular response to heat
A	0042026	biological_process	protein refolding
A	0043335	biological_process	protein unfolding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0009408	biological_process	response to heat
B	0016887	molecular_function	ATP hydrolysis activity
B	0034605	biological_process	cellular response to heat
B	0042026	biological_process	protein refolding
B	0043335	biological_process	protein unfolding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0009408	biological_process	response to heat
C	0016887	molecular_function	ATP hydrolysis activity
C	0034605	biological_process	cellular response to heat
C	0042026	biological_process	protein refolding
C	0043335	biological_process	protein unfolding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0009408	biological_process	response to heat
D	0016887	molecular_function	ATP hydrolysis activity
D	0034605	biological_process	cellular response to heat
D	0042026	biological_process	protein refolding
D	0043335	biological_process	protein unfolding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0009408	biological_process	response to heat
E	0016887	molecular_function	ATP hydrolysis activity
E	0034605	biological_process	cellular response to heat
E	0042026	biological_process	protein refolding
E	0043335	biological_process	protein unfolding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0009408	biological_process	response to heat
F	0016887	molecular_function	ATP hydrolysis activity
F	0034605	biological_process	cellular response to heat
F	0042026	biological_process	protein refolding
F	0043335	biological_process	protein unfolding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue AGS A 1001

Chain	Residue
A	ASP178
A	ALA214
A	ILE349
A	LEU353
A	PRO387
A	ILE391
A	VAL180
A	ILE181
A	PRO208
A	GLY209
A	VAL210
A	GLY211
A	LYS212
A	THR213

site_id	AC2
Number of Residues	17
Details	binding site for residue AGS B 1001

Chain	Residue
A	ALA328
A	ARG331
A	ARG332
B	ASP178
B	PRO179
B	VAL180
B	ILE181
B	PRO208
B	GLY209
B	GLY211
B	LYS212
B	THR213
B	ALA214
B	ILE349
B	LEU353
B	PRO387
B	ILE391

site_id	AC3
Number of Residues	15
Details	binding site for residue ADP B 1002

Chain	Residue
B	ARG569
B	VAL570
B	ILE571
B	PRO606
B	THR607
B	GLY608
B	VAL609
B	GLY610
B	LYS611
B	THR612
B	GLU613
B	ILE774
B	ALA814
B	ARG815
B	LYS818

site_id	AC4
Number of Residues	15
Details	binding site for residue AGS C 1001

Chain	Residue
B	ARG332
C	ASP178
C	PRO179
C	VAL180
C	ILE181
C	ARG183
C	PRO208
C	GLY209
C	VAL210
C	GLY211
C	LYS212
C	THR213
C	ILE349
C	LEU353
C	ILE391

site_id	AC5
Number of Residues	18
Details	binding site for residue AGS C 1003

Chain	Residue
B	ARG756
C	ARG569
C	VAL570
C	ILE571
C	THR607
C	GLY608
C	VAL609
C	GLY610
C	LYS611
C	THR612
C	GLU613
C	ASN719
C	LEU766
C	ILE774
C	GLN778
C	ALA814
C	ARG815
C	LYS818

site_id	AC6
Number of Residues	13
Details	binding site for residue AGS D 1002

Chain	Residue
C	ARG756
D	ILE571
D	THR607
D	GLY608
D	VAL609
D	GLY610
D	LYS611
D	THR612
D	GLU613
D	ILE774
D	GLN778
D	ARG815
D	LYS818

site_id	AC7
Number of Residues	13
Details	binding site for residue ADP F 1001

Chain	Residue
F	GLY211
F	LYS212
F	THR213
F	ALA214
F	ILE349
F	PRO387
F	PRO179
F	VAL180
F	ILE181
F	GLU207
F	PRO208
F	GLY209
F	VAL210

site_id	AC8
Number of Residues	20
Details	binding site for Di-peptide AGS C 1002 and ARG C 332

Chain	Residue
C	LYS199
C	ASN201
C	LYS300
C	ALA304
C	ALA328
C	LEU329
C	GLU330
C	ARG331
C	PHE333
D	PRO179
D	VAL180
D	ILE181
D	VAL210
D	GLY211
D	LYS212
D	THR213
D	ALA214
D	ILE349
D	LEU353
D	PRO387

site_id	AC9
Number of Residues	35
Details	binding site for Di-peptide AGS C 1002 and GLY D 211

Chain	Residue
C	GLY209
C	VAL210
C	LYS212
C	THR213
C	ALA214
C	ILE215
C	ALA328
C	ARG331
C	ARG332
C	ARG756
C	AGS1001
D	PRO179
D	VAL180
D	ILE181
D	GLY209
D	VAL210
D	LYS212
D	THR213
D	ALA214
D	ILE215
D	ILE349
D	LEU353
D	PRO387
D	ILE571
D	THR607
D	GLY608
D	VAL609
D	GLY610
D	LYS611
D	THR612
D	GLU613
D	ILE774
D	GLN778
D	ARG815
D	LYS818

site_id	AD1
Number of Residues	17
Details	binding site for Di-peptide AGS D 1001 and ARG D 332

Chain	Residue
D	LYS300
D	LEU303
D	ALA304
D	ALA328
D	LEU329
D	GLU330
D	ARG331
D	PHE333
E	PRO179
E	ILE181
E	PRO208
E	GLY209
E	GLY211
E	LYS212
E	THR213
E	ILE349
E	LEU353

site_id	AD2
Number of Residues	24
Details	binding site for Di-peptide AGS D 1003 and ARG D 756

Chain	Residue
D	ARG596
D	SER600
D	LEU691
D	ASP695
D	GLU752
D	PHE753
D	ILE754
D	ASN755
D	ILE757
D	ASP758
E	ARG569
E	VAL570
E	ILE571
E	THR607
E	GLY608
E	VAL609
E	GLY610
E	LYS611
E	THR612
E	GLU613
E	ILE774
E	GLN778
E	ARG815
E	LYS818

site_id	AD3
Number of Residues	23
Details	binding site for Di-peptide AGS D 1003 and GLY E 608

Chain	Residue
D	PRO606
D	THR607
D	VAL609
D	GLY610
D	ARG756
D	ALA814
D	AGS1002
E	ARG569
E	VAL570
E	ILE571
E	PRO606
E	THR607
E	VAL609
E	GLY610
E	LYS611
E	THR612
E	GLU613
E	ILE774
E	GLN778
E	GLY813
E	ALA814
E	ARG815
E	LYS818

site_id	AD4
Number of Residues	32
Details	binding site for Di-peptide AGS D 1003 and LYS E 611

Chain	Residue
D	GLY605
D	PRO606
D	GLY610
D	THR612
D	GLU613
D	LEU614
D	CYS615
D	SER718
D	ASN719
D	ARG756
D	PHE763
D	AGS1002
E	ARG569
E	VAL570
E	ILE571
E	LEU604
E	GLY605
E	PRO606
E	THR607
E	GLY608
E	VAL609
E	GLY610
E	THR612
E	GLU613
E	LEU614
E	CYS615
E	SER718
E	PHE763
E	ILE774
E	GLN778
E	ARG815
E	LYS818

site_id	AD5
Number of Residues	31
Details	binding site for Di-peptide AGS E 1001 and GLY F 610

Chain	Residue
D	AGS1003
E	GLY608
E	VAL609
E	LYS611
E	LEU614
E	ARG756
F	PRO179
F	VAL180
F	ILE181
F	GLU207
F	PRO208
F	GLY209
F	VAL210
F	GLY211
F	LYS212
F	THR213
F	ALA214
F	ILE349
F	PRO387
F	PRO606
F	THR607
F	GLY608
F	VAL609
F	LYS611
F	THR612
F	GLU613
F	LEU614
F	ILE774
F	ALA814
F	ARG815
F	LYS818

site_id	AD6
Number of Residues	39
Details	binding site for Di-peptide AGS E 1001 and ARG F 815

Chain	Residue
D	ASP695
D	ASN755
D	ARG756
D	AGS1003
E	ASN755
E	ARG756
E	GLY813
E	ALA814
E	PRO816
E	LEU817
E	LYS818
E	ARG819
F	PRO179
F	VAL180
F	ILE181
F	GLU207
F	PRO208
F	GLY209
F	VAL210
F	GLY211
F	LYS212
F	THR213
F	ALA214
F	ILE349
F	PRO387
F	PRO606
F	THR607
F	GLY608
F	VAL609
F	GLY610
F	LYS611
F	THR612
F	GLU613
F	ILE774
F	ALA814
F	PRO816
F	LEU817
F	LYS818
F	ARG819

site_id	AD7
Number of Residues	40
Details	binding site for Di-peptide AGS E 1001 and LYS F 818

Chain	Residue
D	AGS1003
E	ARG756
E	ALA814
E	ARG815
E	PRO816
E	LEU817
E	ARG819
E	ALA820
E	ILE821
E	GLN822
F	PRO179
F	VAL180
F	ILE181
F	GLU207
F	PRO208
F	GLY209
F	VAL210
F	GLY211
F	LYS212
F	THR213
F	ALA214
F	ILE349
F	PRO387
F	PRO606
F	THR607
F	GLY608
F	VAL609
F	GLY610
F	LYS611
F	THR612
F	GLU613
F	ILE774
F	ALA814
F	ARG815
F	PRO816
F	LEU817
F	ARG819
F	ALA820
F	ILE821
F	GLN822

site_id	AD8
Number of Residues	19
Details	binding site for Di-peptide AGS E 1001 and ARG E 756

Chain	Residue
E	ARG596
E	ASP695
E	GLU752
E	PHE753
E	ILE754
E	ASN755
E	ILE757
F	PRO606
F	THR607
F	GLY608
F	VAL609
F	GLY610
F	LYS611
F	THR612
F	GLU613
F	ILE774
F	ALA814
F	ARG815
F	LYS818

Functional Information from PROSITE/UniProt

site_id	PS00870
Number of Residues	13
Details	CLPAB_1 Chaperonins clpA/B signature 1. DAGNMLKPaLarG

Chain	Residue	Details
A	ASP294-GLY306

site_id	PS00871
Number of Residues	19
Details	CLPAB_2 Chaperonins clpA/B signature 2. RIDmSEFmEKhSvSRLvGA

Chain	Residue	Details
A	ARG631-ALA649

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)