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6Q42

Crystal Structure of Human Pancreatic Phospholipase A2

Functional Information from GO Data
ChainGOidnamespacecontents
A0002227biological_processinnate immune response in mucosa
A0002446biological_processneutrophil mediated immunity
A0004623molecular_functionphospholipase A2 activity
A0005102molecular_functionsignaling receptor binding
A0005509molecular_functioncalcium ion binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006629biological_processlipid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006644biological_processphospholipid metabolic process
A0007015biological_processactin filament organization
A0007165biological_processsignal transduction
A0008284biological_processpositive regulation of cell population proliferation
A0009986cellular_componentcell surface
A0010524biological_processpositive regulation of calcium ion transport into cytosol
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0019370biological_processleukotriene biosynthetic process
A0019731biological_processantibacterial humoral response
A0030593biological_processneutrophil chemotaxis
A0032052molecular_functionbile acid binding
A0032431biological_processactivation of phospholipase A2 activity
A0032757biological_processpositive regulation of interleukin-8 production
A0032869biological_processcellular response to insulin stimulus
A0035556biological_processintracellular signal transduction
A0043406biological_processpositive regulation of MAP kinase activity
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046324biological_processregulation of glucose import
A0046470biological_processphosphatidylcholine metabolic process
A0046471biological_processphosphatidylglycerol metabolic process
A0046872molecular_functionmetal ion binding
A0047498molecular_functioncalcium-dependent phospholipase A2 activity
A0048146biological_processpositive regulation of fibroblast proliferation
A0050482biological_processarachidonic acid secretion
A0050714biological_processpositive regulation of protein secretion
A0050778biological_processpositive regulation of immune response
A0050830biological_processdefense response to Gram-positive bacterium
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A1904635biological_processpositive regulation of podocyte apoptotic process
B0002227biological_processinnate immune response in mucosa
B0002446biological_processneutrophil mediated immunity
B0004623molecular_functionphospholipase A2 activity
B0005102molecular_functionsignaling receptor binding
B0005509molecular_functioncalcium ion binding
B0005543molecular_functionphospholipid binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006629biological_processlipid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0006644biological_processphospholipid metabolic process
B0007015biological_processactin filament organization
B0007165biological_processsignal transduction
B0008284biological_processpositive regulation of cell population proliferation
B0009986cellular_componentcell surface
B0010524biological_processpositive regulation of calcium ion transport into cytosol
B0016042biological_processlipid catabolic process
B0016787molecular_functionhydrolase activity
B0019370biological_processleukotriene biosynthetic process
B0019731biological_processantibacterial humoral response
B0030593biological_processneutrophil chemotaxis
B0032052molecular_functionbile acid binding
B0032431biological_processactivation of phospholipase A2 activity
B0032757biological_processpositive regulation of interleukin-8 production
B0032869biological_processcellular response to insulin stimulus
B0035556biological_processintracellular signal transduction
B0043406biological_processpositive regulation of MAP kinase activity
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046324biological_processregulation of glucose import
B0046470biological_processphosphatidylcholine metabolic process
B0046471biological_processphosphatidylglycerol metabolic process
B0046872molecular_functionmetal ion binding
B0047498molecular_functioncalcium-dependent phospholipase A2 activity
B0048146biological_processpositive regulation of fibroblast proliferation
B0050482biological_processarachidonic acid secretion
B0050714biological_processpositive regulation of protein secretion
B0050778biological_processpositive regulation of immune response
B0050830biological_processdefense response to Gram-positive bacterium
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B1904635biological_processpositive regulation of podocyte apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue CL A 201
ChainResidue
AARG6
AASN23
BLYS121

site_idAC2
Number of Residues4
Detailsbinding site for residue CL A 202
ChainResidue
AASP39
AGLU40
AASN112
AHOH362

site_idAC3
Number of Residues4
Detailsbinding site for residue CL B 201
ChainResidue
BARG6
BASN23
ALYS121
AHOH338

site_idAC4
Number of Residues5
Detailsbinding site for residue CL B 202
ChainResidue
AARG100
BILE82
BARG100
BHOH379
BHOH458

Functional Information from PROSITE/UniProt
site_idPS00118
Number of Residues8
DetailsPA2_HIS Phospholipase A2 histidine active site. CCQtHDnC
ChainResidueDetails
ACYS44-CYS51

site_idPS00119
Number of Residues11
DetailsPA2_ASP Phospholipase A2 aspartic acid active site. ICNCDRNAaIC
ChainResidueDetails
AILE95-CYS105

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P00593
ChainResidueDetails
AHIS48
AASP99
BHIS48
BASP99

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00593
ChainResidueDetails
BGLY32
BASP49
ATYR28
AGLY30
AGLY32
AASP49
BTYR28
BGLY30

219869

PDB entries from 2024-05-15

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