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6N2W

The structure of Stable-5-Lipoxygenase bound to NDGA

Functional Information from GO Data
ChainGOidnamespacecontents
A0001676biological_processlong-chain fatty acid metabolic process
A0001937biological_processnegative regulation of endothelial cell proliferation
A0002232biological_processleukocyte chemotaxis involved in inflammatory response
A0002523biological_processleukocyte migration involved in inflammatory response
A0002540biological_processleukotriene production involved in inflammatory response
A0004051molecular_functionarachidonate 5-lipoxygenase activity
A0004052molecular_functionarachidonate 12(S)-lipoxygenase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005641cellular_componentnuclear envelope lumen
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006690biological_processicosanoid metabolic process
A0006691biological_processleukotriene metabolic process
A0006954biological_processinflammatory response
A0006959biological_processhumoral immune response
A0016020cellular_componentmembrane
A0016363cellular_componentnuclear matrix
A0016525biological_processnegative regulation of angiogenesis
A0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A0016787molecular_functionhydrolase activity
A0019369biological_processarachidonic acid metabolic process
A0019370biological_processleukotriene biosynthetic process
A0019372biological_processlipoxygenase pathway
A0030501biological_processpositive regulation of bone mineralization
A0031965cellular_componentnuclear membrane
A0034440biological_processlipid oxidation
A0034774cellular_componentsecretory granule lumen
A0036336biological_processdendritic cell migration
A0036403molecular_functionarachidonate 8(S)-lipoxygenase activity
A0042593biological_processglucose homeostasis
A0042759biological_processlong-chain fatty acid biosynthetic process
A0045598biological_processregulation of fat cell differentiation
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050727biological_processregulation of inflammatory response
A0050728biological_processnegative regulation of inflammatory response
A0050796biological_processregulation of insulin secretion
A0051213molecular_functiondioxygenase activity
A0061044biological_processnegative regulation of vascular wound healing
A0061045biological_processnegative regulation of wound healing
A0106014biological_processregulation of inflammatory response to wounding
A1900015biological_processregulation of cytokine production involved in inflammatory response
A1900407biological_processregulation of cellular response to oxidative stress
A1901753biological_processleukotriene A4 biosynthetic process
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1903573biological_processnegative regulation of response to endoplasmic reticulum stress
A1903671biological_processnegative regulation of sprouting angiogenesis
A1904813cellular_componentficolin-1-rich granule lumen
A1904999biological_processpositive regulation of leukocyte adhesion to arterial endothelial cell
A2001301biological_processlipoxin biosynthetic process
B0001676biological_processlong-chain fatty acid metabolic process
B0001937biological_processnegative regulation of endothelial cell proliferation
B0002232biological_processleukocyte chemotaxis involved in inflammatory response
B0002523biological_processleukocyte migration involved in inflammatory response
B0002540biological_processleukotriene production involved in inflammatory response
B0004051molecular_functionarachidonate 5-lipoxygenase activity
B0004052molecular_functionarachidonate 12(S)-lipoxygenase activity
B0005506molecular_functioniron ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005641cellular_componentnuclear envelope lumen
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006690biological_processicosanoid metabolic process
B0006691biological_processleukotriene metabolic process
B0006954biological_processinflammatory response
B0006959biological_processhumoral immune response
B0016020cellular_componentmembrane
B0016363cellular_componentnuclear matrix
B0016525biological_processnegative regulation of angiogenesis
B0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B0016787molecular_functionhydrolase activity
B0019369biological_processarachidonic acid metabolic process
B0019370biological_processleukotriene biosynthetic process
B0019372biological_processlipoxygenase pathway
B0030501biological_processpositive regulation of bone mineralization
B0031965cellular_componentnuclear membrane
B0034440biological_processlipid oxidation
B0034774cellular_componentsecretory granule lumen
B0036336biological_processdendritic cell migration
B0036403molecular_functionarachidonate 8(S)-lipoxygenase activity
B0042593biological_processglucose homeostasis
B0042759biological_processlong-chain fatty acid biosynthetic process
B0045598biological_processregulation of fat cell differentiation
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050727biological_processregulation of inflammatory response
B0050728biological_processnegative regulation of inflammatory response
B0050796biological_processregulation of insulin secretion
B0051213molecular_functiondioxygenase activity
B0061044biological_processnegative regulation of vascular wound healing
B0061045biological_processnegative regulation of wound healing
B0106014biological_processregulation of inflammatory response to wounding
B1900015biological_processregulation of cytokine production involved in inflammatory response
B1900407biological_processregulation of cellular response to oxidative stress
B1901753biological_processleukotriene A4 biosynthetic process
B1903426biological_processregulation of reactive oxygen species biosynthetic process
B1903573biological_processnegative regulation of response to endoplasmic reticulum stress
B1903671biological_processnegative regulation of sprouting angiogenesis
B1904813cellular_componentficolin-1-rich granule lumen
B1904999biological_processpositive regulation of leukocyte adhesion to arterial endothelial cell
B2001301biological_processlipoxin biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue FE2 A 701
ChainResidue
AHIS367
AHIS372
AHIS550
AASN554
AILE673

site_idAC2
Number of Residues4
Detailsbinding site for residue FE2 B 701
ChainResidue
BHIS367
BHIS372
BHIS550
BILE673

site_idAC3
Number of Residues10
Detailsbinding site for residue 30Z B 702
ChainResidue
BGLN363
BLEU368
BHIS372
BILE406
BASN407
BPRO569
BARG596
BTRP599
BHIS600
BLEU607

Functional Information from PROSITE/UniProt
site_idPS00081
Number of Residues11
DetailsLIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. VHPIfKLLvAH
ChainResidueDetails
AVAL389-HIS399

site_idPS00711
Number of Residues15
DetailsLIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HQtitHlLRTHLVsE
ChainResidueDetails
AHIS362-GLU376

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY19
BTHR20
BASP21
BGLU46
BARG47
BALA49
BTYR81
BLEU82
ATHR20
AASP21
AGLU46
AARG47
AALA49
ATYR81
ALEU82
BGLY19

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0007744|PDB:3O8Y, ECO:0007744|PDB:3V92, ECO:0007744|PDB:3V98, ECO:0007744|PDB:3V99
ChainResidueDetails
AARG370
ASER375
AVAL553
BARG370
BSER375
BVAL553

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0007744|PDB:3O8Y, ECO:0007744|PDB:3V92, ECO:0007744|PDB:3V99
ChainResidueDetails
AGLN557
BGLN557

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Essential for stabilizing binding to COTL1 => ECO:0000269|PubMed:19807693
ChainResidueDetails
AGLY105
BGLY105

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPKAPK2 => ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:18978352
ChainResidueDetails
AGLN274
BGLN274

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15280375, ECO:0000269|PubMed:26210919
ChainResidueDetails
APRO526
BPRO526

220113

PDB entries from 2024-05-22

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