6KIE
Crystal structure of human leucyl-tRNA synthetase, Leu-AMS-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004819 | molecular_function | glutamine-tRNA ligase activity |
| A | 0004823 | molecular_function | leucine-tRNA ligase activity |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006425 | biological_process | glutaminyl-tRNA aminoacylation |
| A | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| A | 0008361 | biological_process | regulation of cell size |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016604 | cellular_component | nuclear body |
| A | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
| A | 0032008 | biological_process | positive regulation of TOR signaling |
| A | 0034198 | biological_process | cellular response to amino acid starvation |
| A | 0043547 | biological_process | positive regulation of GTPase activity |
| A | 0071230 | biological_process | cellular response to amino acid stimulus |
| A | 0071233 | biological_process | cellular response to L-leucine |
| A | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
| A | 1990253 | biological_process | cellular response to leucine starvation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 1101 |
| Chain | Residue |
| A | THR255 |
| A | GLY256 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 1102 |
| Chain | Residue |
| A | SER718 |
| A | LYS719 |
| A | SER720 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 1103 |
| Chain | Residue |
| A | ASN56 |
| A | ARG517 |
| A | HOH1222 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue LSS A 1104 |
| Chain | Residue |
| A | PRO51 |
| A | TYR52 |
| A | PRO53 |
| A | TYR54 |
| A | GLY62 |
| A | HIS63 |
| A | SER66 |
| A | HIS91 |
| A | HIS251 |
| A | SER597 |
| A | SER673 |
| A | GLY674 |
| A | ASP676 |
| A | LEU677 |
| A | HIS681 |
| A | HIS709 |
| A | LEU710 |
| A | HOH1222 |
| A | PHE50 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue LEU A 1105 |
| Chain | Residue |
| A | THR293 |
| A | LEU294 |
| A | ARG295 |
| A | THR390 |
| A | SER396 |
| A | ASP399 |
| A | TYR468 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PymNGrLHLGHT |
| Chain | Residue | Details |
| A | PRO53-THR64 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:32232361, ECO:0007744|PDB:6LPF |
| Chain | Residue | Details |
| A | TYR54 | |
| A | LEU594 | |
| A | SER597 | |
| A | TYR52 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS719 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER167 | |
| A | SER720 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8BMJ2 |
| Chain | Residue | Details |
| A | LYS970 | |
| A | LYS1047 |
