6J88
Crystal structure of HinD with benzo[b]thiophen analog
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0006707 | biological_process | cholesterol catabolic process |
| B | 0008395 | molecular_function | steroid hydroxylase activity |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0020037 | molecular_function | heme binding |
| B | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | LEU57 |
| A | GLY236 |
| A | THR240 |
| A | GLN243 |
| A | THR286 |
| A | ARG289 |
| A | ALA339 |
| A | PHE340 |
| A | GLY341 |
| A | LEU344 |
| A | HIS345 |
| A | VAL84 |
| A | CYS347 |
| A | LEU348 |
| A | VAL353 |
| A | B9O502 |
| A | MET85 |
| A | HIS92 |
| A | ARG96 |
| A | PHE103 |
| A | ILE148 |
| A | LEU232 |
| A | ALA235 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue B9O A 502 |
| Chain | Residue |
| A | THR82 |
| A | MET85 |
| A | PHE169 |
| A | PHE170 |
| A | VAL231 |
| A | LEU234 |
| A | THR239 |
| A | PHE287 |
| A | HEM501 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | binding site for residue HEM B 501 |
| Chain | Residue |
| B | LEU57 |
| B | VAL84 |
| B | MET85 |
| B | ARG96 |
| B | ILE148 |
| B | LEU232 |
| B | ALA235 |
| B | GLY236 |
| B | THR240 |
| B | THR286 |
| B | ARG289 |
| B | ALA339 |
| B | PHE340 |
| B | GLY341 |
| B | LEU344 |
| B | HIS345 |
| B | HIS346 |
| B | CYS347 |
| B | LEU348 |
| B | GLY349 |
| B | VAL353 |
| B | B9O502 |
| B | HOH615 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue B9O B 502 |
| Chain | Residue |
| B | ILE80 |
| B | THR82 |
| B | MET85 |
| B | PHE169 |
| B | PHE170 |
| B | VAL231 |
| B | THR239 |
| B | LEU281 |
| B | PHE287 |
| B | HEM501 |
| B | HOH615 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGLHHCLG |
| Chain | Residue | Details |
| A | PHE340-GLY349 |
