6IEG
Crystal structure of human MTR4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000176 | cellular_component | nuclear exosome (RNase complex) |
| A | 0000178 | cellular_component | exosome (RNase complex) |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0000460 | biological_process | maturation of 5.8S rRNA |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005681 | cellular_component | spliceosomal complex |
| A | 0005730 | cellular_component | nucleolus |
| A | 0006364 | biological_process | rRNA processing |
| A | 0006397 | biological_process | mRNA processing |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016076 | biological_process | snRNA catabolic process |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0031499 | cellular_component | TRAMP complex |
| A | 0071013 | cellular_component | catalytic step 2 spliceosome |
| B | 0000176 | cellular_component | nuclear exosome (RNase complex) |
| B | 0000178 | cellular_component | exosome (RNase complex) |
| B | 0000398 | biological_process | mRNA splicing, via spliceosome |
| B | 0000460 | biological_process | maturation of 5.8S rRNA |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005681 | cellular_component | spliceosomal complex |
| B | 0005730 | cellular_component | nucleolus |
| B | 0006364 | biological_process | rRNA processing |
| B | 0006397 | biological_process | mRNA processing |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016076 | biological_process | snRNA catabolic process |
| B | 0016607 | cellular_component | nuclear speck |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0031499 | cellular_component | TRAMP complex |
| B | 0071013 | cellular_component | catalytic step 2 spliceosome |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31358741, ECO:0007744|PDB:6RO1 |
| Chain | Residue | Details |
| B | ILE139 | |
| A | ILE139 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 |
| Chain | Residue | Details |
| B | ALA161 | |
| A | ALA161 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:31358741, ECO:0007744|PDB:6C90, ECO:0007744|PDB:6RO1 |
| Chain | Residue | Details |
| A | LYS167 | |
| A | THR168 | |
| B | SER164 | |
| B | GLY166 | |
| B | LYS167 | |
| B | THR168 | |
| A | SER164 | |
| A | GLY166 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9CZU3 |
| Chain | Residue | Details |
| B | LYS78 | |
| A | LYS78 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS723 | |
| A | LYS358 | |
| A | LYS723 | |
| B | LYS358 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS684 | |
| B | LYS684 |
