6HYO
Structure of ULK1 LIR motif bound to GABARAP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000045 | biological_process | autophagosome assembly |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000421 | cellular_component | autophagosome membrane |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005776 | cellular_component | autophagosome |
| A | 0005790 | cellular_component | smooth endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0005875 | cellular_component | microtubule associated complex |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005930 | cellular_component | axoneme |
| A | 0006605 | biological_process | protein targeting |
| A | 0006914 | biological_process | autophagy |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006995 | biological_process | cellular response to nitrogen starvation |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0008429 | molecular_function | phosphatidylethanolamine binding |
| A | 0008625 | biological_process | extrinsic apoptotic signaling pathway via death domain receptors |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0015031 | biological_process | protein transport |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0016020 | cellular_component | membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| A | 0035020 | biological_process | regulation of Rac protein signal transduction |
| A | 0045202 | cellular_component | synapse |
| A | 0048487 | molecular_function | beta-tubulin binding |
| A | 0050811 | molecular_function | GABA receptor binding |
| A | 0097225 | cellular_component | sperm midpiece |
| A | 0097352 | biological_process | autophagosome maturation |
| A | 1902524 | biological_process | positive regulation of protein K48-linked ubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 201 |
| Chain | Residue |
| A | ARG22 |
| A | PRO26 |
| A | ASP27 |
| A | SER53 |
| A | GLY92 |
| A | TYR95 |
| A | GLN96 |
| A | HOH303 |
| A | HOH304 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 202 |
| Chain | Residue |
| A | PHE11 |
| A | ALA72 |
| A | GLU73 |
| A | HOH337 |
| A | HOH423 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue PEG A 203 |
| Chain | Residue |
| A | GLN-5 |
| A | LYS23 |
| A | LYS24 |
| A | PRO26 |
| A | ASP27 |
| A | HOH351 |
| A | HOH378 |
| A | HOH389 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 204 |
| Chain | Residue |
| A | VAL-10 |
| A | LYS38 |
| A | LYS46 |
| A | ARG67 |
| A | HOH395 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue PEG A 205 |
| Chain | Residue |
| A | VAL4 |
| A | GLU34 |
| A | LYS35 |
| A | LYS47 |
| A | HOH307 |
| A | HOH313 |
| A | HOH327 |
| A | HOH341 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 206 |
| Chain | Residue |
| A | ALA-6 |
| A | PHE-4 |
| A | ASP54 |
| A | PEG207 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 207 |
| Chain | Residue |
| A | ALA-6 |
| A | PHE-4 |
| A | ASP54 |
| A | PEG206 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 208 |
| Chain | Residue |
| A | ASP-12 |
| A | LYS46 |
| A | LYS47 |
| A | LYS48 |
| A | HOH317 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Interaction with LIR (LC3 nteracting Region) motif of ATG3 => ECO:0000269|PubMed:37252361, ECO:0007744|PDB:8AFI |
| Chain | Residue | Details |
| A | ARG28 | |
| A | GLU17 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by ATG4B => ECO:0000269|PubMed:15169837 |
| Chain | Residue | Details |
| A | GLY116 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | LIPID: Phosphatidylserine amidated glycine; alternate => ECO:0000269|PubMed:33909989 |
| Chain | Residue | Details |
| A | GLY116 |
