6C90

Human Mtr4 helicase in complex with ZCCHC8-CTD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ADP A 1101

Chain	Residue
A	PHE138
A	ASN490
A	ARG527
A	HOH1295
A	ILE139
A	ASP141
A	GLN144
A	THR163
A	SER164
A	GLY166
A	LYS167
A	THR168

---

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 1102

Chain	Residue
A	TLA1108
A	HOH1347

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 1103

Chain	Residue
A	LEU573
A	LEU574
A	VAL576
A	ILE579
A	HOH1379
A	HOH1399

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MLI A 1104

Chain	Residue
A	ARG854
A	GLU952
A	HOH1221
A	HOH1230
A	HOH1287

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MLI A 1105

Chain	Residue
A	ILE191
A	LYS192
A	ALA193
A	ARG262
A	ARG999
A	HOH1223

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MLI A 1106

Chain	Residue
A	LYS396
A	HIS456
A	GLY457
A	THR482
A	THR484
A	HOH1203

---

site_id	AC7
Number of Residues	3
Details	binding site for residue MLI A 1107

Chain	Residue
A	LEU123
A	LYS126
A	HOH1244

---

site_id	AC8
Number of Residues	4
Details	binding site for residue TLA A 1108

Chain	Residue
A	GLU113
A	ILE286
A	PRO287
A	MG1102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER695

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	ALA161

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:31358741, ECO:0007744|PDB:6C90, ECO:0007744|PDB:6RO1

Chain	Residue	Details
A	THR168
A	SER164
A	GLY166
A	LYS167

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9CZU3

Chain	Residue	Details
A	LYS78

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS358

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