5YLW
CYP76AH1 from Salvia miltiorrhiza
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0016102 | biological_process | diterpenoid biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0016712 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | ARG95 |
| A | THR302 |
| A | ASN303 |
| A | PRO362 |
| A | LEU366 |
| A | ARG369 |
| A | PRO429 |
| A | PHE430 |
| A | GLY431 |
| A | SER432 |
| A | ARG435 |
| A | MET111 |
| A | CYS437 |
| A | PRO438 |
| A | GLY439 |
| A | HOH771 |
| A | GLY112 |
| A | TRP120 |
| A | ARG124 |
| A | PHE132 |
| A | LEU295 |
| A | GLY298 |
| A | GLY299 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 502 |
| Chain | Residue |
| A | HIS102 |
| A | HOH646 |
| A | HOH780 |
| A | HOH902 |
| A | HOH937 |
| A | HOH979 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGsGRRVCPG |
| Chain | Residue | Details |
| A | PHE430-GLY439 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | TOPO_DOM: Lumenal => ECO:0000250|UniProtKB:Q8VWZ7 |
| Chain | Residue | Details |
| A | MET1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP2-PHE22 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 472 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q8VWZ7 |
| Chain | Residue | Details |
| A | ARG23-SER495 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:30837155, ECO:0007744|PDB:5YLW, ECO:0007744|PDB:5YM3 |
| Chain | Residue | Details |
| A | CYS437 |
