Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5XJT

Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2.R61A/F/E/G from Human

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000245	biological_process	spliceosomal complex assembly
2	0000375	biological_process	RNA splicing, via transesterification reactions
2	0000387	biological_process	spliceosomal snRNP assembly
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005681	cellular_component	spliceosomal complex
2	0005730	cellular_component	nucleolus
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0006397	biological_process	mRNA processing
2	0008380	biological_process	RNA splicing
2	0016604	cellular_component	nuclear body
2	0032797	cellular_component	SMN complex
2	0034719	cellular_component	SMN-Sm protein complex
2	0097504	cellular_component	Gemini of coiled bodies
2	1905215	biological_process	negative regulation of RNA binding
A	0000387	biological_process	spliceosomal snRNP assembly
A	0003723	molecular_function	RNA binding
A	0006396	biological_process	RNA processing
B	0000245	biological_process	spliceosomal complex assembly
B	0000387	biological_process	spliceosomal snRNP assembly
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005682	cellular_component	U5 snRNP
B	0005684	cellular_component	U2-type spliceosomal complex
B	0005685	cellular_component	U1 snRNP
B	0005686	cellular_component	U2 snRNP
B	0005687	cellular_component	U4 snRNP
B	0005689	cellular_component	U12-type spliceosomal complex
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0030532	cellular_component	small nuclear ribonucleoprotein complex
B	0034709	cellular_component	methylosome
B	0034715	cellular_component	pICln-Sm protein complex
B	0034719	cellular_component	SMN-Sm protein complex
B	0036261	biological_process	7-methylguanosine cap hypermethylation
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0070062	cellular_component	extracellular exosome
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071007	cellular_component	U2-type catalytic step 2 spliceosome
B	0071011	cellular_component	precatalytic spliceosome
B	0071013	cellular_component	catalytic step 2 spliceosome
B	1903241	biological_process	U2-type prespliceosome assembly
E	0000245	biological_process	spliceosomal complex assembly
E	0000387	biological_process	spliceosomal snRNP assembly
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0005683	cellular_component	U7 snRNP
E	0005684	cellular_component	U2-type spliceosomal complex
E	0005685	cellular_component	U1 snRNP
E	0005686	cellular_component	U2 snRNP
E	0005687	cellular_component	U4 snRNP
E	0005689	cellular_component	U12-type spliceosomal complex
E	0005697	cellular_component	telomerase holoenzyme complex
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0030532	cellular_component	small nuclear ribonucleoprotein complex
E	0034709	cellular_component	methylosome
E	0034715	cellular_component	pICln-Sm protein complex
E	0034719	cellular_component	SMN-Sm protein complex
E	0036261	biological_process	7-methylguanosine cap hypermethylation
E	0043229	cellular_component	intracellular organelle
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	0071005	cellular_component	U2-type precatalytic spliceosome
E	0071007	cellular_component	U2-type catalytic step 2 spliceosome
E	0071011	cellular_component	precatalytic spliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
E	1903241	biological_process	U2-type prespliceosome assembly
F	0000387	biological_process	spliceosomal snRNP assembly
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005682	cellular_component	U5 snRNP
F	0005683	cellular_component	U7 snRNP
F	0005684	cellular_component	U2-type spliceosomal complex
F	0005685	cellular_component	U1 snRNP
F	0005686	cellular_component	U2 snRNP
F	0005687	cellular_component	U4 snRNP
F	0005689	cellular_component	U12-type spliceosomal complex
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0030532	cellular_component	small nuclear ribonucleoprotein complex
F	0034709	cellular_component	methylosome
F	0034715	cellular_component	pICln-Sm protein complex
F	0034719	cellular_component	SMN-Sm protein complex
F	0036261	biological_process	7-methylguanosine cap hypermethylation
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0071005	cellular_component	U2-type precatalytic spliceosome
F	0071007	cellular_component	U2-type catalytic step 2 spliceosome
F	0071013	cellular_component	catalytic step 2 spliceosome
F	0120114	cellular_component	Sm-like protein family complex
F	1903241	biological_process	U2-type prespliceosome assembly
G	0000245	biological_process	spliceosomal complex assembly
G	0000387	biological_process	spliceosomal snRNP assembly
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0005682	cellular_component	U5 snRNP
G	0005683	cellular_component	U7 snRNP
G	0005684	cellular_component	U2-type spliceosomal complex
G	0005685	cellular_component	U1 snRNP
G	0005686	cellular_component	U2 snRNP
G	0005687	cellular_component	U4 snRNP
G	0005689	cellular_component	U12-type spliceosomal complex
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
G	0030532	cellular_component	small nuclear ribonucleoprotein complex
G	0034709	cellular_component	methylosome
G	0034719	cellular_component	SMN-Sm protein complex
G	0036261	biological_process	7-methylguanosine cap hypermethylation
G	0043186	cellular_component	P granule
G	0043229	cellular_component	intracellular organelle
G	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
G	0071004	cellular_component	U2-type prespliceosome
G	0071005	cellular_component	U2-type precatalytic spliceosome
G	0071007	cellular_component	U2-type catalytic step 2 spliceosome
G	0071011	cellular_component	precatalytic spliceosome
G	0071013	cellular_component	catalytic step 2 spliceosome
G	0097526	cellular_component	spliceosomal tri-snRNP complex
G	1903241	biological_process	U2-type prespliceosome assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
M	SER28

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:17487921, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
M	SER31

site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
M	LYS51

site_id	SWS_FT_FI4
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
B	LYS6
B	LYS8

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)