5U6R

E. coli CTP synthase CC mutant filament (product-bound)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003883	molecular_function	CTP synthase activity
A	0004359	molecular_function	glutaminase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0097268	cellular_component	cytoophidium
B	0000287	molecular_function	magnesium ion binding
B	0003883	molecular_function	CTP synthase activity
B	0004359	molecular_function	glutaminase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0097268	cellular_component	cytoophidium
C	0000287	molecular_function	magnesium ion binding
C	0003883	molecular_function	CTP synthase activity
C	0004359	molecular_function	glutaminase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0016874	molecular_function	ligase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0051289	biological_process	protein homotetramerization
C	0097268	cellular_component	cytoophidium
D	0000287	molecular_function	magnesium ion binding
D	0003883	molecular_function	CTP synthase activity
D	0004359	molecular_function	glutaminase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0051289	biological_process	protein homotetramerization
D	0097268	cellular_component	cytoophidium

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue CTP A 601

Chain	Residue
A	ASP147
A	ILE148
A	GLU149
B	GLN114
B	VAL115
B	ILE116
C	THR188
C	LYS189
C	LYS196

---

site_id	AC2
Number of Residues	9
Details	binding site for residue ADP A 602

Chain	Residue
A	LEU16
A	GLY17
A	LYS18
A	ILE20
A	ASP72
A	ARG211
A	LYS239
A	ASP240
A	VAL241

---

site_id	AC3
Number of Residues	8
Details	binding site for residue CTP B 601

Chain	Residue
A	GLN114
B	SER14
B	ASP147
B	ILE148
B	GLU149
D	THR188
D	LYS189
D	LYS196

---

site_id	AC4
Number of Residues	9
Details	binding site for residue ADP B 602

Chain	Residue
B	LEU16
B	GLY17
B	LYS18
B	GLY19
B	ILE20
B	ARG211
B	LYS239
B	ASP240
B	VAL241

---

site_id	AC5
Number of Residues	8
Details	binding site for residue CTP C 601

Chain	Residue
A	THR188
A	LYS189
A	LYS196
C	SER14
C	ASP147
C	ILE148
C	GLU149
D	GLN114

---

site_id	AC6
Number of Residues	10
Details	binding site for residue ADP C 602

Chain	Residue
C	LEU16
C	GLY17
C	LYS18
C	GLY19
C	ILE20
C	ASP72
C	ARG211
C	LYS239
C	ASP240
C	VAL241

---

site_id	AC7
Number of Residues	8
Details	binding site for residue CTP D 601

Chain	Residue
B	THR188
B	LYS189
B	LYS196
C	ILE116
D	SER14
D	ASP147
D	ILE148
D	GLU149

---

site_id	AC8
Number of Residues	9
Details	binding site for residue ADP D 602

Chain	Residue
D	LEU16
D	GLY17
D	LYS18
D	GLY19
D	ILE20
D	ARG211
D	LYS239
D	ASP240
D	VAL241

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile; for glutamine hydrolysis => ECO:0000305|PubMed:11336655, ECO:0000305|PubMed:15157079

Chain	Residue	Details
A	CYS379
B	CYS379
C	CYS379
D	CYS379

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:15157079

Chain	Residue	Details
C	HIS515
C	GLU517
D	HIS515
D	GLU517
A	HIS515
A	GLU517
B	HIS515
B	GLU517

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305|PubMed:16216072

Chain	Residue	Details
B	LYS187
B	LYS223
C	SER14
C	LYS187
C	LYS223
D	SER14
D	LYS187
D	LYS223
A	SER14
A	LYS187
A	LYS223
B	SER14

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305|PubMed:16216072, ECO:0007744|PDB:2AD5

Chain	Residue	Details
B	ASP147
B	LYS239
C	SER15
C	ASP147
C	LYS239
D	SER15
D	ASP147
D	LYS239
A	SER15
A	ASP147
A	LYS239
B	SER15

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:16216072, ECO:0007744|PDB:2AD5

Chain	Residue	Details
A	ASP72
A	GLU140
B	ASP72
B	GLU140
C	ASP72
C	GLU140
D	ASP72
D	GLU140

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01227

Chain	Residue	Details
C	GLY352
C	LEU380
C	GLU403
C	ARG470
D	GLY352
D	LEU380
D	GLU403
D	ARG470
A	GLY352
A	LEU380
A	GLU403
A	ARG470
B	GLY352
B	LEU380
B	GLU403
B	ARG470

---