5THH
Crystal structure of a human tyrosyl-tRNA synthetase mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004831 | molecular_function | tyrosine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006437 | biological_process | tyrosyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue TYR A 401 |
| Chain | Residue |
| A | TYR39 |
| A | GLN182 |
| A | GLN188 |
| A | HOH537 |
| A | HOH571 |
| A | HOH648 |
| A | HOH685 |
| A | GLY41 |
| A | LEU72 |
| A | ALA74 |
| A | HIS77 |
| A | VAL152 |
| A | TYR166 |
| A | GLN170 |
| A | ASP173 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25533949, ECO:0007744|PDB:4Q93 |
| Chain | Residue | Details |
| A | TYR39 | |
| A | GLN170 | |
| A | ASP173 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14671330, ECO:0007744|PDB:4QBT |
| Chain | Residue | Details |
| A | TYR166 | |
| A | GLN188 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS206 | |
| A | LYS197 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER205 |
