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5MZE

Crystal structure of mouse MTH1 with 8-oxo-dGTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001669cellular_componentacrosomal vesicle
A0003723molecular_functionRNA binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006152biological_processpurine nucleoside catabolic process
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0008584biological_processmale gonad development
A0008828molecular_functiondATP diphosphatase activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A0030515molecular_functionsnoRNA binding
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A0042262biological_processDNA protection
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0047693molecular_functionATP diphosphatase activity
A0106377molecular_function2-hydroxy-ATP hydrolase activity
A0106378molecular_function2-hydroxy-dATP hydrolase activity
A0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
A0106433molecular_functionO6-methyl-dGTP hydrolase activity
A0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B0001669cellular_componentacrosomal vesicle
B0003723molecular_functionRNA binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006152biological_processpurine nucleoside catabolic process
B0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B0008584biological_processmale gonad development
B0008828molecular_functiondATP diphosphatase activity
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0030515molecular_functionsnoRNA binding
B0031410cellular_componentcytoplasmic vesicle
B0031965cellular_componentnuclear membrane
B0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B0042262biological_processDNA protection
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0047693molecular_functionATP diphosphatase activity
B0106377molecular_function2-hydroxy-ATP hydrolase activity
B0106378molecular_function2-hydroxy-dATP hydrolase activity
B0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
B0106433molecular_functionO6-methyl-dGTP hydrolase activity
B0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
C0001669cellular_componentacrosomal vesicle
C0003723molecular_functionRNA binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0006152biological_processpurine nucleoside catabolic process
C0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
C0008584biological_processmale gonad development
C0008828molecular_functiondATP diphosphatase activity
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
C0030515molecular_functionsnoRNA binding
C0031410cellular_componentcytoplasmic vesicle
C0031965cellular_componentnuclear membrane
C0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
C0042262biological_processDNA protection
C0046686biological_processresponse to cadmium ion
C0046872molecular_functionmetal ion binding
C0047693molecular_functionATP diphosphatase activity
C0106377molecular_function2-hydroxy-ATP hydrolase activity
C0106378molecular_function2-hydroxy-dATP hydrolase activity
C0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
C0106433molecular_functionO6-methyl-dGTP hydrolase activity
C0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
D0001669cellular_componentacrosomal vesicle
D0003723molecular_functionRNA binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0006152biological_processpurine nucleoside catabolic process
D0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
D0008584biological_processmale gonad development
D0008828molecular_functiondATP diphosphatase activity
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
D0030515molecular_functionsnoRNA binding
D0031410cellular_componentcytoplasmic vesicle
D0031965cellular_componentnuclear membrane
D0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
D0042262biological_processDNA protection
D0046686biological_processresponse to cadmium ion
D0046872molecular_functionmetal ion binding
D0047693molecular_functionATP diphosphatase activity
D0106377molecular_function2-hydroxy-ATP hydrolase activity
D0106378molecular_function2-hydroxy-dATP hydrolase activity
D0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
D0106433molecular_functionO6-methyl-dGTP hydrolase activity
D0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue CU A 201
ChainResidue
AHIS65
AASP89

site_idAC2
Number of Residues2
Detailsbinding site for residue CU A 202
ChainResidue
AHIS90
AHIS92

site_idAC3
Number of Residues8
Detailsbinding site for residue PEG A 203
ChainResidue
CGLN104
CPHE106
CHOH315
AARG102
AGLN104
AHOH341
CTRP32
CARG102

site_idAC4
Number of Residues23
Detailsbinding site for residue 8DG A 204
ChainResidue
ATYR7
ATHR8
ALEU9
ALYS23
APHE27
AASN33
AGLY36
AGLY37
ALYS38
AGLU52
AGLU56
APHE72
AMET81
AGLU100
ATRP117
AASP119
AASP120
ATRP123
AHOH312
AHOH331
AHOH339
AHOH347
AHOH355

site_idAC5
Number of Residues2
Detailsbinding site for residue CU B 201
ChainResidue
BHIS65
BASP89

site_idAC6
Number of Residues6
Detailsbinding site for residue GOL B 202
ChainResidue
BARG17
BTRP105
BGLN107
DARG17
DTRP105
DGLN107

site_idAC7
Number of Residues19
Detailsbinding site for residue 8DG B 203
ChainResidue
BTYR7
BTHR8
BLEU9
BLYS23
BPHE27
BASN33
BGLY36
BGLY37
BLYS38
BGLU52
BPHE72
BMET81
BGLU100
BTRP117
BASP119
BASP120
BTRP123
BHOH327
BHOH345

site_idAC8
Number of Residues1
Detailsbinding site for residue CU C 201
ChainResidue
CASP89

site_idAC9
Number of Residues19
Detailsbinding site for residue 8DG C 202
ChainResidue
CTYR7
CTHR8
CLEU9
CLYS23
CPHE27
CASN33
CGLY36
CGLY37
CLYS38
CGLU52
CPHE72
CMET81
CGLU100
CTRP117
CASP119
CASP120
CTRP123
CHOH313
CHOH317

site_idAD1
Number of Residues8
Detailsbinding site for residue PEG D 201
ChainResidue
BARG102
BGLN104
BHOH302
DTRP32
DARG102
DGLN104
DPHE106
DHOH322

site_idAD2
Number of Residues20
Detailsbinding site for residue 8DG D 202
ChainResidue
DGLU52
DGLU56
DPHE72
DMET81
DGLU100
DTRP117
DASP119
DASP120
DTRP123
DHOH304
DHOH361
DTYR7
DTHR8
DLEU9
DLYS23
DPHE27
DASN33
DGLY36
DGLY37
DLYS38

Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkvqegEtiedGAkRELlEEsG
ChainResidueDetails
AGLY37-GLY58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:29281266, ECO:0007744|PDB:5MZE
ChainResidueDetails
ATHR8
BTRP117
CTHR8
CLYS23
CASN33
CPHE35
CTRP117
DTHR8
DLYS23
DASN33
DPHE35
ALYS23
DTRP117
AASN33
APHE35
ATRP117
BTHR8
BLYS23
BASN33
BPHE35

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q7ZWC3
ChainResidueDetails
AGLY36
BGLU100
CGLY36
CGLU52
CGLU55
CGLU56
CGLU100
DGLY36
DGLU52
DGLU55
DGLU56
AGLU52
DGLU100
AGLU55
AGLU56
AGLU100
BGLY36
BGLU52
BGLU55
BGLU56

221371

PDB entries from 2024-06-19

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