5MZE

Crystal structure of mouse MTH1 with 8-oxo-dGTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	7,8-dihydro-8-oxoguanine triphosphatase	polymer	176	20101.7	4	UniProt (P53368) Pfam (PF00293)	Mus musculus (House Mouse)	2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1
2	E, F, I, L (A, B, C)	COPPER (II) ION	non-polymer		63.5	4	Chemie (CU)
3	G, N (A, D)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
4	H, K, M, O (A, B, C, D)	8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	4	Chemie (8DG)
5	J (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	P, Q, R, S (A, B, C, D)	water	water		18.0	408	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 156 (UniProt: P53368)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80406.6
Non-Polymers*	Number of molecules	11
	Total formula weight	2651.2
All*	Total formula weight	83057.9

*Water molecules are not included.