5KN8

MutY N-terminal domain in complex with undamaged DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0019104	molecular_function	DNA N-glycosylase activity
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SF4 A 301

Chain	Residue
A	ARG153
A	CYS198
A	CYS205
A	CYS208
A	CYS214
A	ALA222

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site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 302

Chain	Residue
A	HOH499
A	HOH507
D	DA21
A	SER118
A	VAL123
A	HOH415

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:19841264

Chain	Residue	Details
A	GLU43

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:19841264

Chain	Residue	Details
A	TRP30
A	TYR126
A	GLU188

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14961129, ECO:0000269|PubMed:19841264

Chain	Residue	Details
A	GLN48
A	LEU86

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:14961129, ECO:0000269|PubMed:19841264, ECO:0000269|PubMed:25995449, ECO:0000269|Ref.3, ECO:0000269|Ref.5, ECO:0007744|PDB:1RRQ, ECO:0007744|PDB:1RRS, ECO:0007744|PDB:1VRL

Chain	Residue	Details
A	CYS198
A	CYS205
A	CYS208
A	CYS214

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000305|PubMed:19841264, ECO:0000305|PubMed:25995449

Chain	Residue	Details
A	ASN144

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 807

Chain	Residue	Details
A	GLU43	activator, proton acceptor, proton donor
A	TYR126	electrostatic stabiliser
A	ASN144	covalently attached, nucleofuge, nucleophile

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