5KKL
Structure of ctPRC2 in complex with H3K27me3 and H3K27M
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8001 |
| Chain | Residue |
| B | CYS727 |
| B | CYS748 |
| B | CYS755 |
| B | CYS760 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8002 |
| Chain | Residue |
| B | CYS736 |
| B | CYS755 |
| B | CYS763 |
| B | CYS784 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8003 |
| Chain | Residue |
| B | CYS729 |
| B | CYS736 |
| B | CYS746 |
| B | CYS727 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 8004 |
| Chain | Residue |
| B | CYS685 |
| B | HIS687 |
| B | CYS691 |
| B | CYS697 |
| B | ZN8005 |
| B | ZN8006 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 8005 |
| Chain | Residue |
| B | CYS691 |
| B | CYS709 |
| B | CYS715 |
| B | CYS720 |
| B | ZN8004 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 8006 |
| Chain | Residue |
| B | CYS685 |
| B | CYS699 |
| B | CYS709 |
| B | CYS713 |
| B | ZN8004 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8007 |
| Chain | Residue |
| B | CYS508 |
| B | CYS511 |
| B | CYS516 |
| B | HIS518 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8008 |
| Chain | Residue |
| B | CYS570 |
| B | CYS574 |
| B | CYS615 |
| B | CYS625 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue SAM B 8009 |
| Chain | Residue |
| B | CYS807 |
| B | GLY808 |
| B | TYR809 |
| B | LYS852 |
| B | VAL853 |
| B | SER854 |
| B | TYR855 |
| B | ARG877 |
| B | TYR878 |
| B | ASN880 |
| B | HIS881 |
| B | TYR918 |
| B | PHE922 |
| B | LEU925 |
| B | THR926 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| D | LYS23 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Citrulline => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| D | ARG26 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| D | M3L27 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| D | SER28 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:15983376, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | ARG2545 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:15983376 |
| Chain | Residue | Details |
| B | PRO2546 |
