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5KDH

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A DIHYDROPYRIDOPYRIMIDINE SCAFFOLD INHIBITOR

Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 6RX A 201
ChainResidue
ATRP81
AHOH342
APRO82
AVAL87
ALEU92
AASN116
AASN140
AILE146
AHOH307
AHOH320

site_idAC2
Number of Residues6
Detailsbinding site for residue EDO A 202
ChainResidue
ASER51
AASN52
ALYS57
ATRP81
ATYR118
AHOH313

site_idAC3
Number of Residues5
Detailsbinding site for residue SO4 A 203
ChainResidue
ALYS57
ALYS91
ALYS99
ALYS102
AHOH306

site_idAC4
Number of Residues2
Detailsbinding site for residue SO4 A 204
ChainResidue
AASP145
AMET149

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

218853

PDB entries from 2024-04-24

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