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5KDH

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A DIHYDROPYRIDOPYRIMIDINE SCAFFOLD INHIBITOR

Summary for 5KDH
Entry DOI10.2210/pdb5kdh/pdb
Related5KJ0
DescriptorBromodomain-containing protein 4, (5~{S})-1-ethyl-5-(4-methylphenyl)-8,9-dihydro-5~{H}-furo[3,4]pyrido[3,5-~{b}]pyrimidine-2,4,6-trione, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsbromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight15692.92
Authors
Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2016-06-08, release date: 2017-08-02, Last modification date: 2023-09-27)
Primary citationAyoub, A.M.,Hawk, L.M.L.,Herzig, R.J.,Jiang, J.,Wisniewski, A.J.,Gee, C.T.,Zhao, P.,Zhu, J.Y.,Berndt, N.,Offei-Addo, N.K.,Scott, T.G.,Qi, J.,Bradner, J.E.,Ward, T.R.,Schonbrunn, E.,Georg, G.I.,Pomerantz, W.C.K.
BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.
J. Med. Chem., 60:4805-4817, 2017
Cited by
PubMed: 28535045
DOI: 10.1021/acs.jmedchem.6b01336
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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