5KAR
Murine acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004767 | molecular_function | sphingomyelin phosphodiesterase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006685 | biological_process | sphingomyelin catabolic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0034122 | biological_process | negative regulation of toll-like receptor signaling pathway |
| A | 0045087 | biological_process | innate immune response |
| A | 0045824 | biological_process | negative regulation of innate immune response |
| A | 0046466 | biological_process | membrane lipid catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050728 | biological_process | negative regulation of inflammatory response |
| A | 0098552 | cellular_component | side of membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27687724, ECO:0007744|PDB:5KAR, ECO:0007744|PDB:5KAS |
| Chain | Residue | Details |
| A | ASN134 | |
| A | HIS236 | |
| A | HIS277 | |
| A | HIS279 | |
| A | ASP93 | |
| A | ASP28 | |
| A | HIS30 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:27687724, ECO:0007744|PDB:5KAR, ECO:0007744|PDB:5KAS |
| Chain | Residue | Details |
| A | ASN34 | |
| A | ASN223 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27687724, ECO:0007744|PDB:5KAR, ECO:0007744|PDB:5KAS |
| Chain | Residue | Details |
| A | ASN72 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN100 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| A | ASN164 |
