5JEM

Complex of IRF-3 with CBP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
C	0000123	cellular_component	histone acetyltransferase complex
C	0003713	molecular_function	transcription coactivator activity
C	0004402	molecular_function	histone acetyltransferase activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
D	0000123	cellular_component	histone acetyltransferase complex
D	0003713	molecular_function	transcription coactivator activity
D	0004402	molecular_function	histone acetyltransferase activity
D	0005634	cellular_component	nucleus
D	0006355	biological_process	regulation of DNA-templated transcription
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
F	0000123	cellular_component	histone acetyltransferase complex
F	0003713	molecular_function	transcription coactivator activity
F	0004402	molecular_function	histone acetyltransferase activity
F	0005634	cellular_component	nucleus
F	0006355	biological_process	regulation of DNA-templated transcription
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0006355	biological_process	regulation of DNA-templated transcription
H	0000123	cellular_component	histone acetyltransferase complex
H	0003713	molecular_function	transcription coactivator activity
H	0004402	molecular_function	histone acetyltransferase activity
H	0005634	cellular_component	nucleus
H	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
C	SER2076
G	THR237
G	THR244
G	THR253
C	SER2079
D	SER2076
D	SER2079
F	SER2076
F	SER2079
H	SER2076
H	SER2079
E	THR253

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:22394562

Chain	Residue	Details
A	SER385
B	SER385
E	SER385
G	SER385

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579

Chain	Residue	Details
A	GLU386
B	GLU386
E	GLU386
G	GLU386

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by IKKE and TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579

Chain	Residue	Details
A	GLU396
B	GLU396
E	GLU396
G	GLU396

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site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:23746807

Chain	Residue	Details
A	SER398
B	SER398
E	SER398
G	SER398

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site_id	SWS_FT_FI6
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:20308324

Chain	Residue	Details
A	LYS193
E	LYS360
E	LYS366
G	LYS193
G	LYS360
G	LYS366
A	LYS360
A	LYS366
B	LYS193
B	LYS360
B	LYS366
E	LYS193

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