5JEI

Crystal structure of the GluA2 LBD in complex with FW

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue FWD A 301

Chain	Residue
A	TYR61
A	THR174
A	LEU192
A	GLU193
A	MET196
A	HOH464
A	HOH476
A	HOH612
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143

---

site_id	AC2
Number of Residues	8
Details	binding site for residue PO4 A 302

Chain	Residue
A	LYS20
A	GLU30
A	TRP159
A	ARG163
A	HOH411
A	HOH452
A	HOH495
A	HOH595

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PO4 A 303

Chain	Residue
A	HIS23
A	GLU24
A	ARG31
A	HOH529
A	HOH678

---

site_id	AC4
Number of Residues	6
Details	binding site for residue PG4 A 304

Chain	Residue
A	GLU201
A	LYS210
A	GLY227
A	ETE310
A	HOH410
A	HOH559

---

site_id	AC5
Number of Residues	6
Details	binding site for residue PEG A 305

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	ASP248
A	HOH426
A	HOH540

---

site_id	AC6
Number of Residues	10
Details	binding site for residue TOE A 306

Chain	Residue
A	PRO105
A	SER217
A	LYS218
A	GLY219
A	ASN242
A	ASP248
A	HOH431
A	HOH625
A	HOH649
A	HOH655

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PG4 A 307

Chain	Residue
A	LYS144
A	TRP159
A	PHE170
A	HOH417

---

site_id	AC8
Number of Residues	7
Details	binding site for residue PG0 A 308

Chain	Residue
A	LYS4
A	VAL7
A	GLY81
A	LYS82
A	ASP84
A	PRO205
A	HOH509

---

site_id	AC9
Number of Residues	7
Details	binding site for residue ETE A 309

Chain	Residue
A	VAL6
A	SER228
A	SER229
A	GLY262
A	SER263
A	HOH607
A	HOH627

---

site_id	AD1
Number of Residues	13
Details	binding site for residue ETE A 310

Chain	Residue
A	LYS117
A	GLU201
A	GLN202
A	PRO225
A	LYS226
A	SER228
A	CYS261
A	GLY262
A	SER263
A	PG4304
A	HOH449
A	HOH711
A	HOH752

---

site_id	AD2
Number of Residues	5
Details	binding site for residue PEG A 311

Chain	Residue
A	GLU33
A	THR160
A	HOH401
A	HOH428
A	HOH637

---

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO A 312

Chain	Residue
A	SER14
A	HOH450
A	HOH463
A	HOH466
A	HOH516

---

site_id	AD4
Number of Residues	6
Details	binding site for residue PEG A 313

Chain	Residue
A	THR131
A	ILE133
A	TYR161
A	HOH405
A	HOH408
A	HOH456

---

site_id	AD5
Number of Residues	1
Details	binding site for residue NA A 314

Chain	Residue
A	GLU198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16483599

Chain	Residue	Details
A	TYR61
A	ARG96
A	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	PRO89

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	THR91
A	SER142
A	THR143

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

---