5H1M
Crystal structure of WD40 repeat domains of Gemin5 in complex with M7G
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue M7G A 801 |
| Chain | Residue |
| A | TYR474 |
| A | THR540 |
| A | GLU541 |
| A | ASN582 |
| A | TYR660 |
| A | LEU686 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. CATSsdDgTVKIWDV |
| Chain | Residue | Details |
| A | CYS82-VAL96 | |
| A | LEU395-THR409 | |
| A | LEU655-ALA669 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Interaction with U4 snRNA => ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0007744|PDB:5GXH, ECO:0007744|PDB:5GXI, ECO:0007744|PDB:5H1K, ECO:0007744|PDB:5H1L |
| Chain | Residue | Details |
| A | ARG33 | |
| A | PHE381 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Interaction with U4 snRNA => ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881601, ECO:0007744|PDB:5H1K |
| Chain | Residue | Details |
| A | ARG284 | |
| A | ARG335 | |
| A | TRP422 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Interaction with U4 snRNA => ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0007744|PDB:5GXI, ECO:0007744|PDB:5H1K, ECO:0007744|PDB:5H1L |
| Chain | Residue | Details |
| A | ARG359 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Interaction with U4 snRNA => ECO:0000269|PubMed:27881601, ECO:0007744|PDB:5H1K |
| Chain | Residue | Details |
| A | LYS470 | |
| A | GLU556 | |
| A | LYS579 | |
| A | LYS426 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules => ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881601, ECO:0000269|Ref.27, ECO:0007744|PDB:5H1M, ECO:0007744|PDB:5TEF |
| Chain | Residue | Details |
| A | TYR474 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules => ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881601, ECO:0000269|Ref.27, ECO:0007744|PDB:5H1K, ECO:0007744|PDB:5TEF |
| Chain | Residue | Details |
| A | LYS641 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules => ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881601, ECO:0000269|Ref.27, ECO:0007744|PDB:5H1K, ECO:0007744|PDB:5H1M, ECO:0007744|PDB:5TEF |
| Chain | Residue | Details |
| A | TYR660 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules => ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0007744|PDB:5GXH, ECO:0007744|PDB:5H1K |
| Chain | Residue | Details |
| A | ARG684 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER48 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR51 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER624 |
