5EUL
Structure of the SecA-SecY complex with a translocating polypeptide substrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006605 | biological_process | protein targeting |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0017038 | biological_process | protein import |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006605 | biological_process | protein targeting |
| E | 0006886 | biological_process | intracellular protein transport |
| E | 0008320 | molecular_function | protein transmembrane transporter activity |
| E | 0009306 | biological_process | protein secretion |
| E | 0015031 | biological_process | protein transport |
| E | 0016020 | cellular_component | membrane |
| E | 0043952 | biological_process | protein transport by the Sec complex |
| E | 0065002 | biological_process | intracellular protein transmembrane transport |
| Y | 0005048 | molecular_function | signal sequence binding |
| Y | 0005886 | cellular_component | plasma membrane |
| Y | 0006605 | biological_process | protein targeting |
| Y | 0006616 | biological_process | SRP-dependent cotranslational protein targeting to membrane, translocation |
| Y | 0008320 | molecular_function | protein transmembrane transporter activity |
| Y | 0015031 | biological_process | protein transport |
| Y | 0016020 | cellular_component | membrane |
| Y | 0031522 | cellular_component | cell envelope Sec protein transport complex |
| Y | 0043952 | biological_process | protein transport by the Sec complex |
| Y | 0065002 | biological_process | intracellular protein transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue MG A 1001 |
| Chain | Residue |
| A | ADP1003 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue BEF A 1002 |
| Chain | Residue |
| A | THR102 |
| A | GLY103 |
| A | ASP492 |
| A | ADP1003 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue ADP A 1003 |
| Chain | Residue |
| A | GLY103 |
| A | GLY105 |
| A | LYS106 |
| A | THR107 |
| A | LEU108 |
| A | ASP492 |
| A | ARG528 |
| A | GLN529 |
| A | MG1001 |
| A | BEF1002 |
| A | MET79 |
| A | PHE80 |
| A | PHE82 |
| A | GLN85 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue TBR A 1004 |
| Chain | Residue |
| A | ASP591 |
| A | GLN595 |
| A | GLN598 |
| A | TYR599 |
| Y | GLU103 |
| Y | ARG106 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue TBR A 1005 |
| Chain | Residue |
| A | GLU798 |
| A | MET801 |
| A | GLU802 |
| Y | PRO263 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue TBR A 1006 |
| Chain | Residue |
| A | THR251 |
| A | ASP253 |
| A | THR256 |
| A | VAL298 |
| A | ALA299 |
| A | MET300 |
| A | GLU544 |
| A | ARG547 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue TBR A 1007 |
| Chain | Residue |
| A | LYS302 |
| A | ASP303 |
| A | GLU443 |
| A | LYS447 |
| A | LYS462 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue TBR A 1008 |
| Chain | Residue |
| A | HIS43 |
| A | GLU47 |
| A | GLU50 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue TBR A 1009 |
| Chain | Residue |
| A | THR120 |
| A | HIS202 |
| A | ASP276 |
| A | GLU365 |
| A | LYS366 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue TBR A 1010 |
| Chain | Residue |
| A | GLU625 |
| A | GLU628 |
| A | ASN629 |
| A | MET689 |
| A | ILE693 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue TBR A 1011 |
| Chain | Residue |
| A | LYS723 |
| A | ASP726 |
| A | HIS809 |
| A | SER813 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue TBR A 1012 |
| Chain | Residue |
| A | ASP773 |
| A | GLU778 |
| A | GLU780 |
| Y | SER289 |
| Y | ARG301 |
| Y | ARG302 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue TBR A 1013 |
| Chain | Residue |
| A | LYS229 |
| A | LYS232 |
| A | TYR234 |
| A | ALA285 |
| A | HIS288 |
| A | HIS289 |
| A | GLU348 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue TBR A 1014 |
| Chain | Residue |
| A | GLU309 |
| A | ASP310 |
| A | LYS325 |
| A | LYS462 |
| A | HIS464 |
| A | GLU465 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue TBR A 1015 |
| Chain | Residue |
| A | GLU443 |
| A | SER446 |
| A | LYS450 |
| A | VAL458 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue TBR A 1016 |
| Chain | Residue |
| A | GLU34 |
| A | GLU71 |
| A | ARG74 |
| A | ARG75 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue TBR A 1017 |
| Chain | Residue |
| A | THR376 |
| A | GLU379 |
| A | LYS583 |
| A | GLU586 |
| A | PHE590 |
| Y | MET104 |
| Y | ARG107 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue TBR A 1018 |
| Chain | Residue |
| A | ARG14 |
| A | GLU378 |
| A | GLU379 |
| A | GLN388 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue TBR Y 501 |
| Chain | Residue |
| Y | PRO242 |
| A | GLU50 |
| A | GLU53 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue TBR Y 502 |
| Chain | Residue |
| A | PHE804 |
| Y | GLU417 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue TBR Y 503 |
| Chain | Residue |
| A | ARG553 |
| Y | LYS94 |
| Y | GLU97 |
Functional Information from PROSITE/UniProt
| site_id | PS00755 |
| Number of Residues | 20 |
| Details | SECY_1 Protein secY signature 1. SIFaMGVmPYItASIIVQLL |
| Chain | Residue | Details |
| Y | SER68-LEU87 |
| site_id | PS00756 |
| Number of Residues | 18 |
| Details | SECY_2 Protein secY signature 2. WLgEqITak.GVGNGiSII |
| Chain | Residue | Details |
| Y | TRP165-ILE182 |
| site_id | PS01312 |
| Number of Residues | 16 |
| Details | SECA SecA family signature. VtIATNMAGRGtDIkL |
| Chain | Residue | Details |
| A | VAL480-LEU495 |
| site_id | PS01067 |
| Number of Residues | 29 |
| Details | SECE_SEC61G Protein secE/sec61-gamma signature. FfKEvVreLkKvsWPnrkElvnytAVVLA |
| Chain | Residue | Details |
| E | PHE7-ALA35 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15256599, ECO:0000269|PubMed:19850053, ECO:0007744|PDB:1TF2, ECO:0007744|PDB:3JV2 |
| Chain | Residue | Details |
| A | MET79 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01382, ECO:0000269|PubMed:12242434, ECO:0000269|PubMed:15256599, ECO:0000269|PubMed:16989859, ECO:0000269|PubMed:19850053, ECO:0007744|PDB:1M74, ECO:0007744|PDB:1TF2, ECO:0007744|PDB:2IBM, ECO:0007744|PDB:3JV2 |
| Chain | Residue | Details |
| A | GLY103 | |
| A | GLN85 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01382, ECO:0000269|PubMed:12242434, ECO:0000269|PubMed:15256599, ECO:0000269|PubMed:16989859, ECO:0007744|PDB:1M74, ECO:0007744|PDB:1TF2, ECO:0007744|PDB:2IBM |
| Chain | Residue | Details |
| A | ASP492 |
