5DH3

Crystal structure of MST2 in complex with XMU-MP-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 5BS A 401

Chain	Residue
A	LEU33
A	GLU100
A	TYR101
A	CYS102
A	GLY103
A	GLY105
A	ASP109
A	LEU153
A	ASP164

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 402

Chain	Residue
A	LYS132

---

site_id	AC3
Number of Residues	11
Details	binding site for residue 5BS B 401

Chain	Residue
B	LEU33
B	VAL41
B	ALA54
B	GLU100
B	TYR101
B	CYS102
B	ASP109
B	LEU153
B	ALA163
B	LYS298
B	HOH525

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 402

Chain	Residue
B	CYS102
B	GLY103
B	ASN155
B	THR156

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGSYGSVFkAihkesgqv..........VAIK

Chain	Residue	Details
A	LEU33-LYS56

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ASP146
B	ASP146

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU33
B	LEU33

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	LYS56
B	LYS56

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:29063833, ECO:0007744|PDB:6AO5

Chain	Residue	Details
A	ASN151
A	ASP164
B	ASN151
B	ASP164

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PLK1 => ECO:0000269|PubMed:21723128, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER15
B	SER15

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902

Chain	Residue	Details
A	THR117
B	THR117

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470

Chain	Residue	Details
A	TPO174
B	TPO174

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:29063833

Chain	Residue	Details
A	TPO180
B	TPO180

---