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5DH3

Crystal structure of MST2 in complex with XMU-MP-1

Summary for 5DH3
Entry DOI10.2210/pdb5dh3/pdb
DescriptorSerine/threonine-protein kinase 3, 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsmst2, mst1, hippo pathway, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : Q13188
Total number of polymer chains2
Total formula weight72443.98
Authors
Kong, L.L.,Yun, C.H. (deposition date: 2015-08-29, release date: 2016-08-31, Last modification date: 2023-11-08)
Primary citationFan, F.,He, Z.,Kong, L.L.,Chen, Q.,Yuan, Q.,Zhang, S.,Ye, J.,Liu, H.,Sun, X.,Geng, J.,Yuan, L.,Hong, L.,Xiao, C.,Zhang, W.,Sun, X.,Li, Y.,Wang, P.,Huang, L.,Wu, X.,Ji, Z.,Wu, Q.,Xia, N.S.,Gray, N.S.,Chen, L.,Yun, C.H.,Deng, X.,Zhou, D.
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
Sci Transl Med, 8:352ra108-352ra108, 2016
Cited by
PubMed: 27535619
DOI: 10.1126/scitranslmed.aaf2304
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.468 Å)
Structure validation

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