Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5B6B

Complex of LATS1 and phosphomimetic MOB1b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0019209	molecular_function	kinase activator activity
A	0019900	molecular_function	kinase binding
A	0030295	molecular_function	protein kinase activator activity
A	0031952	biological_process	regulation of protein autophosphorylation
A	0035329	biological_process	hippo signaling
A	0046872	molecular_function	metal ion binding
B	0001934	biological_process	positive regulation of protein phosphorylation
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0019209	molecular_function	kinase activator activity
B	0019900	molecular_function	kinase binding
B	0030295	molecular_function	protein kinase activator activity
B	0031952	biological_process	regulation of protein autophosphorylation
B	0035329	biological_process	hippo signaling
B	0046872	molecular_function	metal ion binding
D	0001934	biological_process	positive regulation of protein phosphorylation
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0019209	molecular_function	kinase activator activity
D	0019900	molecular_function	kinase binding
D	0030295	molecular_function	protein kinase activator activity
D	0031952	biological_process	regulation of protein autophosphorylation
D	0035329	biological_process	hippo signaling
D	0046872	molecular_function	metal ion binding
F	0001934	biological_process	positive regulation of protein phosphorylation
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0019209	molecular_function	kinase activator activity
F	0019900	molecular_function	kinase binding
F	0030295	molecular_function	protein kinase activator activity
F	0031952	biological_process	regulation of protein autophosphorylation
F	0035329	biological_process	hippo signaling
F	0046872	molecular_function	metal ion binding
H	0001934	biological_process	positive regulation of protein phosphorylation
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0019209	molecular_function	kinase activator activity
H	0019900	molecular_function	kinase binding
H	0030295	molecular_function	protein kinase activator activity
H	0031952	biological_process	regulation of protein autophosphorylation
H	0035329	biological_process	hippo signaling
H	0046872	molecular_function	metal ion binding
K	0001934	biological_process	positive regulation of protein phosphorylation
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0019209	molecular_function	kinase activator activity
K	0019900	molecular_function	kinase binding
K	0030295	molecular_function	protein kinase activator activity
K	0031952	biological_process	regulation of protein autophosphorylation
K	0035329	biological_process	hippo signaling
K	0046872	molecular_function	metal ion binding
M	0001934	biological_process	positive regulation of protein phosphorylation
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0019209	molecular_function	kinase activator activity
M	0019900	molecular_function	kinase binding
M	0030295	molecular_function	protein kinase activator activity
M	0031952	biological_process	regulation of protein autophosphorylation
M	0035329	biological_process	hippo signaling
M	0046872	molecular_function	metal ion binding
O	0001934	biological_process	positive regulation of protein phosphorylation
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0019209	molecular_function	kinase activator activity
O	0019900	molecular_function	kinase binding
O	0030295	molecular_function	protein kinase activator activity
O	0031952	biological_process	regulation of protein autophosphorylation
O	0035329	biological_process	hippo signaling
O	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 301

Chain	Residue
A	ARG154
A	ARG157

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 302

Chain	Residue
A	CYS79
A	CYS84
A	ALA111
A	HIS161
A	HIS166

site_id	AC3
Number of Residues	1
Details	binding site for residue CL B 301

Chain	Residue
B	ARG157

site_id	AC4
Number of Residues	5
Details	binding site for residue ZN B 302

Chain	Residue
B	CYS84
B	ALA111
B	HIS161
B	HIS166
B	CYS79

site_id	AC5
Number of Residues	1
Details	binding site for residue CL D 301

Chain	Residue
D	ARG157

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN D 302

Chain	Residue
D	CYS79
D	CYS84
D	ALA111
D	HIS161
D	HIS166

site_id	AC7
Number of Residues	1
Details	binding site for residue CL F 301

Chain	Residue
F	ARG157

site_id	AC8
Number of Residues	5
Details	binding site for residue ZN F 302

Chain	Residue
F	CYS79
F	CYS84
F	ALA111
F	HIS161
F	HIS166

site_id	AC9
Number of Residues	1
Details	binding site for residue CL H 301

Chain	Residue
H	ARG157

site_id	AD1
Number of Residues	5
Details	binding site for residue ZN H 302

Chain	Residue
H	CYS79
H	CYS84
H	ALA111
H	HIS161
H	HIS166

site_id	AD2
Number of Residues	1
Details	binding site for residue CL K 301

Chain	Residue
K	ARG157

site_id	AD3
Number of Residues	5
Details	binding site for residue ZN K 302

Chain	Residue
K	CYS79
K	CYS84
K	ALA111
K	HIS161
K	HIS166

site_id	AD4
Number of Residues	1
Details	binding site for residue CL M 301

Chain	Residue
M	ARG157

site_id	AD5
Number of Residues	5
Details	binding site for residue ZN M 302

Chain	Residue
M	CYS79
M	CYS84
M	ALA111
M	HIS161
M	HIS166

site_id	AD6
Number of Residues	5
Details	binding site for residue ZN O 301

Chain	Residue
O	CYS79
O	CYS84
O	ALA111
O	HIS161
O	HIS166

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:O95835

Chain	Residue	Details
J	SER673
C	SER673
E	SER673
G	SER673
I	SER673
L	SER673
N	SER673
P	SER673
D	CYS79
D	CYS84
D	HIS161
D	HIS166
F	CYS79
F	CYS84
F	HIS161
F	HIS166
H	CYS79
H	CYS84
H	HIS161
H	HIS166
K	CYS79
K	CYS84
K	HIS161
K	HIS166
M	CYS79
M	CYS84
M	HIS161
M	HIS166
O	CYS79
O	CYS84
O	HIS161
O	HIS166

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylserine => ECO:0000250\|UniProtKB:Q7L9L4

Chain	Residue	Details
A	SER2
B	SER2
D	SER2
F	SER2
H	SER2
K	SER2
M	SER2
O	SER2

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: Phosphothreonine; by STK4/MST1 => ECO:0000250\|UniProtKB:Q7L9L4

Chain	Residue	Details
A	ASP12
A	ASP35
B	ASP12
B	ASP35
D	ASP12
D	ASP35
F	ASP12
F	ASP35
H	ASP12
H	ASP35
K	ASP12
K	ASP35
M	ASP12
M	ASP35
O	ASP12
O	ASP35

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)