5B48

2-Oxoacid:Ferredoxin Oxidoreductase 1 from Sulfolobus tokodai

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0016903	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors
A	0018491	molecular_function	2-oxobutyrate synthase activity
A	0019164	molecular_function	pyruvate synthase activity
A	0047553	molecular_function	2-oxoglutarate synthase activity
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
B	0016491	molecular_function	oxidoreductase activity
B	0018491	molecular_function	2-oxobutyrate synthase activity
B	0019164	molecular_function	pyruvate synthase activity
B	0030976	molecular_function	thiamine pyrophosphate binding
B	0046872	molecular_function	metal ion binding
B	0047553	molecular_function	2-oxoglutarate synthase activity
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0003824	molecular_function	catalytic activity
C	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
C	0006979	biological_process	response to oxidative stress
C	0016491	molecular_function	oxidoreductase activity
C	0016903	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors
C	0018491	molecular_function	2-oxobutyrate synthase activity
C	0019164	molecular_function	pyruvate synthase activity
C	0047553	molecular_function	2-oxoglutarate synthase activity
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
D	0016491	molecular_function	oxidoreductase activity
D	0018491	molecular_function	2-oxobutyrate synthase activity
D	0019164	molecular_function	pyruvate synthase activity
D	0030976	molecular_function	thiamine pyrophosphate binding
D	0046872	molecular_function	metal ion binding
D	0047553	molecular_function	2-oxoglutarate synthase activity
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SF4 B 401

Chain	Residue
B	CYS12
B	CYS15
B	CYS46
B	CYS197
B	THR199

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site_id	AC2
Number of Residues	23
Details	binding site for residue TDN B 402

Chain	Residue
A	LEU322
A	ARG344
A	THR349
A	PRO352
B	ILE44
B	GLY45
B	CYS46
B	SER47
B	HIS65
B	ASP90
B	GLY91
B	ASP92
B	ASN118
B	VAL120
B	TYR121
B	GLY122
B	LEU123
B	MG403
C	GLU325
A	TYR253
A	PRO254
A	GLU294
A	PRO318

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site_id	AC3
Number of Residues	4
Details	binding site for residue MG B 403

Chain	Residue
B	ASP90
B	ASN118
B	VAL120
B	TDN402

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:27619895, ECO:0007744|PDB:5B48

Chain	Residue	Details
B	CYS197
D	CYS12
D	CYS15
D	CYS46
D	ASP90
D	GLY91
D	ASN118
D	VAL120
D	GLY122
D	CYS197
B	CYS12
B	CYS15
B	CYS46
B	ASP90
B	GLY91
B	ASN118
B	VAL120
B	GLY122

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q96XT4

Chain	Residue	Details
D	ILE44
D	HIS65
B	ILE44
B	HIS65

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Plays an important role in the binding of CoA => ECO:0000269|PubMed:19027887

Chain	Residue	Details
D	LYS125
B	LYS125

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