Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5AIR

Structural analysis of mouse GSK3beta fused with LRP6 peptide.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000320biological_processre-entry into mitotic cell cycle
A0001558biological_processregulation of cell growth
A0001837biological_processepithelial to mesenchymal transition
A0002039molecular_functionp53 binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0005977biological_processglycogen metabolic process
A0006366biological_processtranscription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006611biological_processprotein export from nucleus
A0006983biological_processER overload response
A0007010biological_processcytoskeleton organization
A0007127biological_processmeiosis I
A0007163biological_processestablishment or maintenance of cell polarity
A0007399biological_processnervous system development
A0007409biological_processaxonogenesis
A0007520biological_processmyoblast fusion
A0007623biological_processcircadian rhythm
A0008013molecular_functionbeta-catenin binding
A0008286biological_processinsulin receptor signaling pathway
A0009887biological_processanimal organ morphogenesis
A0009968biological_processnegative regulation of signal transduction
A0010043biological_processresponse to zinc ion
A0010508biological_processpositive regulation of autophagy
A0010614biological_processnegative regulation of cardiac muscle hypertrophy
A0010628biological_processpositive regulation of gene expression
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0010918biological_processpositive regulation of mitochondrial membrane potential
A0010975biological_processregulation of neuron projection development
A0010977biological_processnegative regulation of neuron projection development
A0014043biological_processnegative regulation of neuron maturation
A0014069cellular_componentpostsynaptic density
A0014902biological_processmyotube differentiation
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016477biological_processcell migration
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0019901molecular_functionprotein kinase binding
A0030010biological_processestablishment of cell polarity
A0030011biological_processmaintenance of cell polarity
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0030516biological_processregulation of axon extension
A0030877cellular_componentbeta-catenin destruction complex
A0031175biological_processneuron projection development
A0032007biological_processnegative regulation of TOR signaling
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032886biological_processregulation of microtubule-based process
A0032991cellular_componentprotein-containing complex
A0033690biological_processpositive regulation of osteoblast proliferation
A0034392biological_processnegative regulation of smooth muscle cell apoptotic process
A0035255molecular_functionionotropic glutamate receptor binding
A0035372biological_processprotein localization to microtubule
A0035556biological_processintracellular signal transduction
A0035729biological_processcellular response to hepatocyte growth factor stimulus
A0035733biological_processhepatic stellate cell activation
A0036016biological_processcellular response to interleukin-3
A0042752biological_processregulation of circadian rhythm
A0042981biological_processregulation of apoptotic process
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043197cellular_componentdendritic spine
A0043198cellular_componentdendritic shaft
A0043227cellular_componentmembrane-bounded organelle
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0043525biological_processpositive regulation of neuron apoptotic process
A0045444biological_processfat cell differentiation
A0045667biological_processregulation of osteoblast differentiation
A0045672biological_processpositive regulation of osteoclast differentiation
A0045724biological_processpositive regulation of cilium assembly
A0045732biological_processpositive regulation of protein catabolic process
A0045773biological_processpositive regulation of axon extension
A0045886biological_processnegative regulation of synaptic assembly at neuromuscular junction
A0045887biological_processpositive regulation of synaptic assembly at neuromuscular junction
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046825biological_processregulation of protein export from nucleus
A0046827biological_processpositive regulation of protein export from nucleus
A0046849biological_processbone remodeling
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048471cellular_componentperinuclear region of cytoplasm
A0048511biological_processrhythmic process
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0048675biological_processaxon extension
A0048814biological_processregulation of dendrite morphogenesis
A0048863biological_processstem cell differentiation
A0050321molecular_functiontau-protein kinase activity
A0050770biological_processregulation of axonogenesis
A0050774biological_processnegative regulation of dendrite morphogenesis
A0051093biological_processnegative regulation of developmental process
A0051128biological_processregulation of cellular component organization
A0060070biological_processcanonical Wnt signaling pathway
A0061049biological_processcell growth involved in cardiac muscle cell development
A0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A0070507biological_processregulation of microtubule cytoskeleton organization
A0070840molecular_functiondynein complex binding
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071260biological_processcellular response to mechanical stimulus
A0071385biological_processcellular response to glucocorticoid stimulus
A0072687cellular_componentmeiotic spindle
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0090290biological_processpositive regulation of osteoclast proliferation
A0097191biological_processextrinsic apoptotic signaling pathway
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097284biological_processhepatocyte apoptotic process
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A0106027biological_processneuron projection organization
A0106310molecular_functionprotein serine kinase activity
A0120283molecular_functionprotein serine/threonine kinase binding
A0141068biological_processautosome genomic imprinting
A1900181biological_processnegative regulation of protein localization to nucleus
A1900271biological_processregulation of long-term synaptic potentiation
A1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
A1901984biological_processnegative regulation of protein acetylation
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903566biological_processpositive regulation of protein localization to cilium
A1904339biological_processnegative regulation of dopaminergic neuron differentiation
A1904646biological_processcellular response to amyloid-beta
A1904780biological_processnegative regulation of protein localization to centrosome
A1904886biological_processbeta-catenin destruction complex disassembly
A1990904cellular_componentribonucleoprotein complex
A1990909cellular_componentWnt signalosome
A2000171biological_processnegative regulation of dendrite development
A2000463biological_processpositive regulation of excitatory postsynaptic potential
A2000573biological_processpositive regulation of DNA biosynthetic process
A2000727biological_processpositive regulation of cardiac muscle cell differentiation
A2000738biological_processpositive regulation of stem cell differentiation
A2001223biological_processnegative regulation of neuron migration
B0000166molecular_functionnucleotide binding
B0000320biological_processre-entry into mitotic cell cycle
B0001558biological_processregulation of cell growth
B0001837biological_processepithelial to mesenchymal transition
B0002039molecular_functionp53 binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0005886cellular_componentplasma membrane
B0005977biological_processglycogen metabolic process
B0006366biological_processtranscription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006611biological_processprotein export from nucleus
B0006983biological_processER overload response
B0007010biological_processcytoskeleton organization
B0007127biological_processmeiosis I
B0007163biological_processestablishment or maintenance of cell polarity
B0007399biological_processnervous system development
B0007409biological_processaxonogenesis
B0007520biological_processmyoblast fusion
B0007623biological_processcircadian rhythm
B0008013molecular_functionbeta-catenin binding
B0008286biological_processinsulin receptor signaling pathway
B0009887biological_processanimal organ morphogenesis
B0009968biological_processnegative regulation of signal transduction
B0010043biological_processresponse to zinc ion
B0010508biological_processpositive regulation of autophagy
B0010614biological_processnegative regulation of cardiac muscle hypertrophy
B0010628biological_processpositive regulation of gene expression
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0010918biological_processpositive regulation of mitochondrial membrane potential
B0010975biological_processregulation of neuron projection development
B0010977biological_processnegative regulation of neuron projection development
B0014043biological_processnegative regulation of neuron maturation
B0014069cellular_componentpostsynaptic density
B0014902biological_processmyotube differentiation
B0016020cellular_componentmembrane
B0016055biological_processWnt signaling pathway
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016477biological_processcell migration
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0019901molecular_functionprotein kinase binding
B0030010biological_processestablishment of cell polarity
B0030011biological_processmaintenance of cell polarity
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030426cellular_componentgrowth cone
B0030516biological_processregulation of axon extension
B0030877cellular_componentbeta-catenin destruction complex
B0031175biological_processneuron projection development
B0032007biological_processnegative regulation of TOR signaling
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032886biological_processregulation of microtubule-based process
B0032991cellular_componentprotein-containing complex
B0033690biological_processpositive regulation of osteoblast proliferation
B0034392biological_processnegative regulation of smooth muscle cell apoptotic process
B0035255molecular_functionionotropic glutamate receptor binding
B0035372biological_processprotein localization to microtubule
B0035556biological_processintracellular signal transduction
B0035729biological_processcellular response to hepatocyte growth factor stimulus
B0035733biological_processhepatic stellate cell activation
B0036016biological_processcellular response to interleukin-3
B0042752biological_processregulation of circadian rhythm
B0042981biological_processregulation of apoptotic process
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043197cellular_componentdendritic spine
B0043198cellular_componentdendritic shaft
B0043227cellular_componentmembrane-bounded organelle
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0043525biological_processpositive regulation of neuron apoptotic process
B0045444biological_processfat cell differentiation
B0045667biological_processregulation of osteoblast differentiation
B0045672biological_processpositive regulation of osteoclast differentiation
B0045724biological_processpositive regulation of cilium assembly
B0045732biological_processpositive regulation of protein catabolic process
B0045773biological_processpositive regulation of axon extension
B0045886biological_processnegative regulation of synaptic assembly at neuromuscular junction
B0045887biological_processpositive regulation of synaptic assembly at neuromuscular junction
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046825biological_processregulation of protein export from nucleus
B0046827biological_processpositive regulation of protein export from nucleus
B0046849biological_processbone remodeling
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048471cellular_componentperinuclear region of cytoplasm
B0048511biological_processrhythmic process
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0048675biological_processaxon extension
B0048814biological_processregulation of dendrite morphogenesis
B0048863biological_processstem cell differentiation
B0050321molecular_functiontau-protein kinase activity
B0050770biological_processregulation of axonogenesis
B0050774biological_processnegative regulation of dendrite morphogenesis
B0051093biological_processnegative regulation of developmental process
B0051128biological_processregulation of cellular component organization
B0060070biological_processcanonical Wnt signaling pathway
B0061049biological_processcell growth involved in cardiac muscle cell development
B0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
B0070507biological_processregulation of microtubule cytoskeleton organization
B0070840molecular_functiondynein complex binding
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071260biological_processcellular response to mechanical stimulus
B0071385biological_processcellular response to glucocorticoid stimulus
B0072687cellular_componentmeiotic spindle
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090290biological_processpositive regulation of osteoclast proliferation
B0097191biological_processextrinsic apoptotic signaling pathway
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0097284biological_processhepatocyte apoptotic process
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0106027biological_processneuron projection organization
B0106310molecular_functionprotein serine kinase activity
B0120283molecular_functionprotein serine/threonine kinase binding
B0141068biological_processautosome genomic imprinting
B1900181biological_processnegative regulation of protein localization to nucleus
B1900271biological_processregulation of long-term synaptic potentiation
B1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
B1901984biological_processnegative regulation of protein acetylation
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1903566biological_processpositive regulation of protein localization to cilium
B1904339biological_processnegative regulation of dopaminergic neuron differentiation
B1904646biological_processcellular response to amyloid-beta
B1904780biological_processnegative regulation of protein localization to centrosome
B1904886biological_processbeta-catenin destruction complex disassembly
B1990904cellular_componentribonucleoprotein complex
B1990909cellular_componentWnt signalosome
B2000171biological_processnegative regulation of dendrite development
B2000463biological_processpositive regulation of excitatory postsynaptic potential
B2000573biological_processpositive regulation of DNA biosynthetic process
B2000727biological_processpositive regulation of cardiac muscle cell differentiation
B2000738biological_processpositive regulation of stem cell differentiation
B2001223biological_processnegative regulation of neuron migration
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK
ChainResidueDetails
AILE62-LYS86

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL
ChainResidueDetails
AILE177-LEU189

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP181
BASP181

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE62
ALYS85
BILE62
BLYS85

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK3 => ECO:0000269|PubMed:22057101, ECO:0000269|PubMed:23395175, ECO:0000269|PubMed:24742671, ECO:0000269|PubMed:27827363
ChainResidueDetails
ASER9
BSER9

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P49841
ChainResidueDetails
ATYR216
BTYR216

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:15345747
ChainResidueDetails
ASER389
BSER389

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon