4ZZL

MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032993	cellular_component	protein-DNA complex
A	0034763	biological_process	negative regulation of transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0050709	biological_process	negative regulation of protein secretion
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0006355	biological_process	regulation of DNA-templated transcription
B	0032993	cellular_component	protein-DNA complex
B	0034763	biological_process	negative regulation of transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0050709	biological_process	negative regulation of protein secretion

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 1140

Chain	Residue
B	PRO37
B	VAL40
B	HIS41
B	MET112
B	HIS116
B	HOH2063

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 1141

Chain	Residue
B	ALA129
B	THR130
B	HOH2061

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