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4XR8

Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0006974biological_processDNA damage response
A0008643biological_processcarbohydrate transport
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0015768biological_processmaltose transport
A0016020cellular_componentmembrane
A0030288cellular_componentouter membrane-bounded periplasmic space
A0034219biological_processcarbohydrate transmembrane transport
A0034289biological_processdetection of maltose stimulus
A0042597cellular_componentperiplasmic space
A0042956biological_processmaltodextrin transmembrane transport
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A0055085biological_processtransmembrane transport
A0060326biological_processcell chemotaxis
A0071702biological_processorganic substance transport
A1901982molecular_functionmaltose binding
A1990060cellular_componentmaltose transport complex
B0005515molecular_functionprotein binding
B0006974biological_processDNA damage response
B0008643biological_processcarbohydrate transport
B0015144molecular_functioncarbohydrate transmembrane transporter activity
B0015768biological_processmaltose transport
B0016020cellular_componentmembrane
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034219biological_processcarbohydrate transmembrane transport
B0034289biological_processdetection of maltose stimulus
B0042597cellular_componentperiplasmic space
B0042956biological_processmaltodextrin transmembrane transport
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B0055085biological_processtransmembrane transport
B0060326biological_processcell chemotaxis
B0071702biological_processorganic substance transport
B1901982molecular_functionmaltose binding
B1990060cellular_componentmaltose transport complex
C0000976molecular_functiontranscription cis-regulatory region binding
C0003677molecular_functionDNA binding
C0003700molecular_functionDNA-binding transcription factor activity
C0005634cellular_componentnucleus
C0006355biological_processregulation of DNA-templated transcription
C0006915biological_processapoptotic process
D0000976molecular_functiontranscription cis-regulatory region binding
D0003677molecular_functionDNA binding
D0003700molecular_functionDNA-binding transcription factor activity
D0005634cellular_componentnucleus
D0006355biological_processregulation of DNA-templated transcription
D0006915biological_processapoptotic process
F0003677molecular_functionDNA binding
F0005515molecular_functionprotein binding
F0006351biological_processDNA-templated transcription
F0006355biological_processregulation of DNA-templated transcription
F0019049biological_processvirus-mediated perturbation of host defense response
F0030162biological_processregulation of proteolysis
F0030165molecular_functionPDZ domain binding
F0030430cellular_componenthost cell cytoplasm
F0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
F0039503biological_processobsolete suppression by virus of host innate immune response
F0039526biological_processobsolete perturbation by virus of host apoptosis
F0039548biological_processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
F0039648biological_processsymbiont-mediated perturbation of host ubiquitin-like protein modification
F0039653biological_processsymbiont-mediated suppression of host transcription
F0042025cellular_componenthost cell nucleus
F0042802molecular_functionidentical protein binding
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046872molecular_functionmetal ion binding
F0090630biological_processactivation of GTPase activity
H0003677molecular_functionDNA binding
H0005515molecular_functionprotein binding
H0006351biological_processDNA-templated transcription
H0006355biological_processregulation of DNA-templated transcription
H0019049biological_processvirus-mediated perturbation of host defense response
H0030162biological_processregulation of proteolysis
H0030165molecular_functionPDZ domain binding
H0030430cellular_componenthost cell cytoplasm
H0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
H0039503biological_processobsolete suppression by virus of host innate immune response
H0039526biological_processobsolete perturbation by virus of host apoptosis
H0039548biological_processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
H0039648biological_processsymbiont-mediated perturbation of host ubiquitin-like protein modification
H0039653biological_processsymbiont-mediated suppression of host transcription
H0042025cellular_componenthost cell nucleus
H0042802molecular_functionidentical protein binding
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0046872molecular_functionmetal ion binding
H0090630biological_processactivation of GTPase activity
Functional Information from PROSITE/UniProt
site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO108-ASN125

site_idPS00348
Number of Residues13
DetailsP53 p53 family signature. MCNSSCMGGMNRR
ChainResidueDetails
CMET237-ARG249

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues144
DetailsZN_FING: ZN_FING => ECO:0000255|HAMAP-Rule:MF_04006
ChainResidueDetails
FCYS30-CYS66
FCYS103-CYS139
HCYS30-CYS66
HCYS103-CYS139
DSER215
DVAL218
DCYS277
DASP281

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130
ChainResidueDetails
CALA159
DALA159

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by TAF1 and GRK5 => ECO:0000269|PubMed:15053879, ECO:0000269|PubMed:20124405
ChainResidueDetails
CSER94
DSER94

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; by KAT6A => ECO:0000269|PubMed:23431171
ChainResidueDetails
CALA159
DALA159

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462
ChainResidueDetails
CPRO222
DPRO222

Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 438
ChainResidueDetails

site_idMCSA2
Number of Residues
DetailsM-CSA 438
ChainResidueDetails

218853

PDB entries from 2024-04-24

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