4XR8
Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution
Summary for 4XR8
Entry DOI | 10.2210/pdb4xr8/pdb |
Related | 4GIZ |
Related PRD ID | PRD_900001 |
Descriptor | Maltose-binding periplasmic protein, ubiquitin ligase E6AP, Cellular tumor antigen p53, Protein E6, ... (8 entities in total) |
Functional Keywords | human papillomavirus 16, e6 oncoprotein, ubiquitin-ligase e6ap, tumor suppressor p53, p53 degradation, viral protein-antitumor protein, viral protein- antitumor protein complex, viral protein/ antitumor protein |
Biological source | Escherichia coli More |
Total number of polymer chains | 6 |
Total formula weight | 166669.39 |
Authors | Martinez-Zapien, D.,Ruiz, F.X.,Mitschler, A.,Podjarny, A.,Trave, G.,Zanier, K. (deposition date: 2015-01-20, release date: 2016-02-03, Last modification date: 2024-01-10) |
Primary citation | Martinez-Zapien, D.,Ruiz, F.X.,Poirson, J.,Mitschler, A.,Ramirez, J.,Forster, A.,Cousido-Siah, A.,Masson, M.,Pol, S.V.,Podjarny, A.,Trave, G.,Zanier, K. Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature, 529:541-545, 2016 Cited by PubMed: 26789255DOI: 10.1038/nature16481 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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