4ORX

Three-dimensional structure of the C65A-K59A double mutant of Human lipocalin-type Prostaglandin D Synthase holo-form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0036094	molecular_function	small molecule binding
B	0036094	molecular_function	small molecule binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	ARG42
A	LYS66
A	THR183
A	ASP184
A	MET187

---

site_id	AC2
Number of Residues	28
Details	BINDING SITE FOR RESIDUE PEU B 201

Chain	Residue
A	ALA59
A	LEU62
A	SER81
A	MET94
A	TRP112
A	TYR116
A	SER133
A	PHE143
A	MET145
A	TYR149
A	HOH316
B	ASN51
B	SER52
B	LEU55
B	ARG92
B	MET94
B	TRP112
B	PRO139
B	ASP142
B	PHE143
B	MET145
B	TYR149
B	HOH311
B	HOH320
A	ASN51
A	SER52
A	TRP54
A	LEU55

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	14
Details	LIPOCALIN Lipocalin signature. NFQqdKFLGRWFSA

Chain	Residue	Details
A	ASN33-ALA46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:20667974

Chain	Residue	Details
A	ALA65
B	ALA65

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:23234360

Chain	Residue	Details
A	SER29
B	SER29

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:8336134

Chain	Residue	Details
A	ASN51
B	ASN51

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:8336134

Chain	Residue	Details
A	ASN78
B	ASN78

---