4NRE
The structure of human 15-lipoxygenase-2 with a substrate mimic
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001676 | biological_process | long-chain fatty acid metabolic process |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005912 | cellular_component | adherens junction |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0006690 | biological_process | icosanoid metabolic process |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0008289 | molecular_function | lipid binding |
| A | 0010744 | biological_process | positive regulation of macrophage derived foam cell differentiation |
| A | 0016020 | cellular_component | membrane |
| A | 0016165 | molecular_function | linoleate 13S-lipoxygenase activity |
| A | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| A | 0019369 | biological_process | arachidonic acid metabolic process |
| A | 0019372 | biological_process | lipoxygenase pathway |
| A | 0030336 | biological_process | negative regulation of cell migration |
| A | 0030850 | biological_process | prostate gland development |
| A | 0030856 | biological_process | regulation of epithelial cell differentiation |
| A | 0032722 | biological_process | positive regulation of chemokine production |
| A | 0034440 | biological_process | lipid oxidation |
| A | 0035360 | biological_process | positive regulation of peroxisome proliferator activated receptor signaling pathway |
| A | 0036403 | molecular_function | arachidonate 8(S)-lipoxygenase activity |
| A | 0043651 | biological_process | linoleic acid metabolic process |
| A | 0045618 | biological_process | positive regulation of keratinocyte differentiation |
| A | 0045786 | biological_process | negative regulation of cell cycle |
| A | 0045926 | biological_process | negative regulation of growth |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050473 | molecular_function | arachidonate 15-lipoxygenase activity |
| A | 0051122 | biological_process | hepoxilin biosynthetic process |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070161 | cellular_component | anchoring junction |
| A | 0071926 | biological_process | endocannabinoid signaling pathway |
| A | 1901696 | biological_process | cannabinoid biosynthetic process |
| A | 1990136 | molecular_function | linoleate 9S-lipoxygenase activity |
| A | 2001303 | biological_process | lipoxin A4 biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 A 701 |
| Chain | Residue |
| A | HIS373 |
| A | HIS378 |
| A | HIS553 |
| A | ILE676 |
| A | HOH801 |
| A | HOH803 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE C8E A 702 |
| Chain | Residue |
| A | HIS378 |
| A | ILE412 |
| A | ALA416 |
| A | LEU420 |
| A | ASP602 |
| A | LEU610 |
| A | LEU78 |
| A | GLU369 |
| A | HIS373 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE C8E A 703 |
| Chain | Residue |
| A | SER190 |
| A | GLU194 |
| A | ILE197 |
| A | ASP202 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 704 |
| Chain | Residue |
| A | ARG5 |
| A | ARG7 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 705 |
| Chain | Residue |
| A | SER277 |
| A | ALA280 |
| A | ARG461 |
| A | HOH869 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 706 |
| Chain | Residue |
| A | LYS198 |
| A | LYS198 |
| A | ARG215 |
| A | ARG215 |
| A | ASN218 |
| A | ASN218 |
| A | HOH906 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 707 |
| Chain | Residue |
| A | ARG252 |
| A | ARG253 |
| A | CYS254 |
| A | HIS255 |
| A | HIS255 |
| A | TYR256 |
| A | TYR256 |
| A | HOH867 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 708 |
| Chain | Residue |
| A | SER296 |
| A | GLY297 |
| A | ALA312 |
| A | LEU333 |
| A | SER334 |
| A | GLN335 |
| A | HOH858 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 709 |
| Chain | Residue |
| A | LYS350 |
| A | TRP351 |
| A | HOH993 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 710 |
| Chain | Residue |
| A | SER177 |
| A | TYR408 |
| A | ASP616 |
| A | ARG618 |
| A | HOH939 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 711 |
| Chain | Residue |
| A | GLY11 |
| A | GLU12 |
| A | ALA13 |
| A | PHE88 |
| A | ARG90 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 712 |
| Chain | Residue |
| A | ASP349 |
| A | LYS350 |
| A | HOH840 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 713 |
| Chain | Residue |
| A | GLN646 |
| A | ARG649 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 714 |
| Chain | Residue |
| A | ARG208 |
| A | SER209 |
| A | ASN211 |
| A | GLU212 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 715 |
| Chain | Residue |
| A | GLN233 |
| A | GLU234 |
| A | ASP235 |
| A | HOH847 |
| A | HOH1148 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 716 |
| Chain | Residue |
| A | GLY15 |
| A | GLY17 |
| A | ASP85 |
| A | ALA86 |
| A | HOH828 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 717 |
| Chain | Residue |
| A | ASP39 |
| A | ASN40 |
| A | GLY42 |
| A | GLU44 |
| A | HOH895 |
| site_id | BC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 718 |
| Chain | Residue |
| A | ALA554 |
| A | SER557 |
| A | ALA558 |
| A | SER611 |
| A | GLU613 |
| A | LEU669 |
| A | ILE676 |
| A | HOH865 |
| A | HOH944 |
| A | HOH945 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 719 |
| Chain | Residue |
| A | VAL75 |
| A | LYS196 |
| A | ASP202 |
| A | ARG429 |
| A | HOH1144 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 720 |
| Chain | Residue |
| A | TRP127 |
| A | SER501 |
| A | ASP504 |
Functional Information from PROSITE/UniProt
| site_id | PS00081 |
| Number of Residues | 11 |
| Details | LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. CHPLfKLLiPH |
| Chain | Residue | Details |
| A | CYS395-HIS405 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCSAKH |
| Chain | Residue | Details |
| A | PHE547-HIS553 |
| site_id | PS00711 |
| Number of Residues | 15 |
| Details | LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HEaltHlLHSHLLpE |
| Chain | Residue | Details |
| A | HIS368-GLU382 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24497644 |
| Chain | Residue | Details |
| A | GLY15 | |
| A | GLY17 | |
| A | ASP39 | |
| A | ASN40 | |
| A | GLY42 | |
| A | GLU44 | |
| A | ASP85 | |
| A | ALA86 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00726, ECO:0000269|PubMed:24497644 |
| Chain | Residue | Details |
| A | HIS373 | |
| A | HIS378 | |
| A | HIS553 | |
| A | ILE676 |
