4N90

Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
R	0045569	molecular_function	TRAIL binding
S	0045569	molecular_function	TRAIL binding
T	0045569	molecular_function	TRAIL binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	CYS230
B	CYS230
C	CYS230

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Functional Information from PROSITE/UniProt

site_id	PS00652
Number of Residues	41
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Ckygqd.Ysthwndllf.ClrCtr.Cdsgevelsp..Ctttr..NTVC

Chain	Residue	Details
R	CYS44-CYS84
R	CYS84-CYS125

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site_id	PS00251
Number of Residues	17
Details	TNF_1 TNF family signature. LvIHeKGFYYIysQTyF

Chain	Residue	Details
A	LEU174-PHE190

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
E	TYR193-HIS199
D	TYR203-HIS209

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518, ECO:0007744|PDB:5CIR

Chain	Residue	Details
A	CYS230
B	CYS230
C	CYS230

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