4LY6
Nucleotide-induced asymmetry within ATPase activator ring drives s54-RNAP interaction and ATP hydrolysis
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005524 | molecular_function | ATP binding |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
A | 0008134 | molecular_function | transcription factor binding |
A | 0016887 | molecular_function | ATP hydrolysis activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0008134 | molecular_function | transcription factor binding |
B | 0016887 | molecular_function | ATP hydrolysis activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006355 | biological_process | regulation of DNA-templated transcription |
C | 0008134 | molecular_function | transcription factor binding |
C | 0016887 | molecular_function | ATP hydrolysis activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006355 | biological_process | regulation of DNA-templated transcription |
D | 0008134 | molecular_function | transcription factor binding |
D | 0016887 | molecular_function | ATP hydrolysis activity |
E | 0005524 | molecular_function | ATP binding |
E | 0006355 | biological_process | regulation of DNA-templated transcription |
E | 0008134 | molecular_function | transcription factor binding |
E | 0016887 | molecular_function | ATP hydrolysis activity |
F | 0005524 | molecular_function | ATP binding |
F | 0006355 | biological_process | regulation of DNA-templated transcription |
F | 0008134 | molecular_function | transcription factor binding |
F | 0016887 | molecular_function | ATP hydrolysis activity |
G | 0005524 | molecular_function | ATP binding |
G | 0006355 | biological_process | regulation of DNA-templated transcription |
G | 0008134 | molecular_function | transcription factor binding |
G | 0016887 | molecular_function | ATP hydrolysis activity |
H | 0005524 | molecular_function | ATP binding |
H | 0006355 | biological_process | regulation of DNA-templated transcription |
H | 0008134 | molecular_function | transcription factor binding |
H | 0016887 | molecular_function | ATP hydrolysis activity |
I | 0005524 | molecular_function | ATP binding |
I | 0006355 | biological_process | regulation of DNA-templated transcription |
I | 0008134 | molecular_function | transcription factor binding |
I | 0016887 | molecular_function | ATP hydrolysis activity |
J | 0005524 | molecular_function | ATP binding |
J | 0006355 | biological_process | regulation of DNA-templated transcription |
J | 0008134 | molecular_function | transcription factor binding |
J | 0016887 | molecular_function | ATP hydrolysis activity |
K | 0005524 | molecular_function | ATP binding |
K | 0006355 | biological_process | regulation of DNA-templated transcription |
K | 0008134 | molecular_function | transcription factor binding |
K | 0016887 | molecular_function | ATP hydrolysis activity |
L | 0005524 | molecular_function | ATP binding |
L | 0006355 | biological_process | regulation of DNA-templated transcription |
L | 0008134 | molecular_function | transcription factor binding |
L | 0016887 | molecular_function | ATP hydrolysis activity |
M | 0005524 | molecular_function | ATP binding |
M | 0006355 | biological_process | regulation of DNA-templated transcription |
M | 0008134 | molecular_function | transcription factor binding |
M | 0016887 | molecular_function | ATP hydrolysis activity |
N | 0005524 | molecular_function | ATP binding |
N | 0006355 | biological_process | regulation of DNA-templated transcription |
N | 0008134 | molecular_function | transcription factor binding |
N | 0016887 | molecular_function | ATP hydrolysis activity |
O | 0005524 | molecular_function | ATP binding |
O | 0006355 | biological_process | regulation of DNA-templated transcription |
O | 0008134 | molecular_function | transcription factor binding |
O | 0016887 | molecular_function | ATP hydrolysis activity |
P | 0005524 | molecular_function | ATP binding |
P | 0006355 | biological_process | regulation of DNA-templated transcription |
P | 0008134 | molecular_function | transcription factor binding |
P | 0016887 | molecular_function | ATP hydrolysis activity |
Q | 0005524 | molecular_function | ATP binding |
Q | 0006355 | biological_process | regulation of DNA-templated transcription |
Q | 0008134 | molecular_function | transcription factor binding |
Q | 0016887 | molecular_function | ATP hydrolysis activity |
R | 0005524 | molecular_function | ATP binding |
R | 0006355 | biological_process | regulation of DNA-templated transcription |
R | 0008134 | molecular_function | transcription factor binding |
R | 0016887 | molecular_function | ATP hydrolysis activity |
S | 0005524 | molecular_function | ATP binding |
S | 0006355 | biological_process | regulation of DNA-templated transcription |
S | 0008134 | molecular_function | transcription factor binding |
S | 0016887 | molecular_function | ATP hydrolysis activity |
T | 0005524 | molecular_function | ATP binding |
T | 0006355 | biological_process | regulation of DNA-templated transcription |
T | 0008134 | molecular_function | transcription factor binding |
T | 0016887 | molecular_function | ATP hydrolysis activity |
U | 0005524 | molecular_function | ATP binding |
U | 0006355 | biological_process | regulation of DNA-templated transcription |
U | 0008134 | molecular_function | transcription factor binding |
U | 0016887 | molecular_function | ATP hydrolysis activity |
V | 0005524 | molecular_function | ATP binding |
V | 0006355 | biological_process | regulation of DNA-templated transcription |
V | 0008134 | molecular_function | transcription factor binding |
V | 0016887 | molecular_function | ATP hydrolysis activity |
W | 0005524 | molecular_function | ATP binding |
W | 0006355 | biological_process | regulation of DNA-templated transcription |
W | 0008134 | molecular_function | transcription factor binding |
W | 0016887 | molecular_function | ATP hydrolysis activity |
X | 0005524 | molecular_function | ATP binding |
X | 0006355 | biological_process | regulation of DNA-templated transcription |
X | 0008134 | molecular_function | transcription factor binding |
X | 0016887 | molecular_function | ATP hydrolysis activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 08T A 400 |
Chain | Residue |
A | TYR139 |
A | ASN280 |
A | VAL356 |
A | ARG357 |
A | LYS360 |
A | MG401 |
B | ASP295 |
B | ARG299 |
A | VAL140 |
A | SER169 |
A | GLY170 |
A | GLY172 |
A | LYS173 |
A | GLU174 |
A | ASP238 |
A | GLU239 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG A 401 |
Chain | Residue |
A | ASP238 |
A | GLU239 |
A | 08T400 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 08T B 400 |
Chain | Residue |
B | VAL140 |
B | SER169 |
B | GLY170 |
B | GLY172 |
B | LYS173 |
B | GLU174 |
B | GLU239 |
B | ASN280 |
B | LEU320 |
B | ARG357 |
B | MG401 |
C | GLU256 |
C | ASP295 |
C | ARG299 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG B 401 |
Chain | Residue |
B | ASP238 |
B | GLU239 |
B | 08T400 |
site_id | AC5 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 08T C 400 |
Chain | Residue |
C | TYR139 |
C | SER169 |
C | GLY170 |
C | VAL171 |
C | GLY172 |
C | LYS173 |
C | GLU174 |
C | VAL175 |
C | GLU239 |
C | ASN280 |
C | VAL356 |
C | ARG357 |
C | MG401 |
D | ARG299 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG C 401 |
Chain | Residue |
C | ASP238 |
C | 08T400 |
site_id | AC7 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 08T D 400 |
Chain | Residue |
D | TYR139 |
D | VAL140 |
D | SER169 |
D | GLY170 |
D | VAL171 |
D | GLY172 |
D | LYS173 |
D | GLU174 |
D | ASP238 |
D | GLU239 |
D | ASN280 |
D | VAL356 |
D | ARG357 |
D | MG401 |
E | ARG299 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG D 401 |
Chain | Residue |
D | ASP238 |
D | 08T400 |
site_id | AC9 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 08T E 400 |
Chain | Residue |
E | TYR139 |
E | SER169 |
E | GLY170 |
E | VAL171 |
E | GLY172 |
E | LYS173 |
E | GLU174 |
E | GLU239 |
E | ASN280 |
E | ARG313 |
E | VAL356 |
E | ARG357 |
E | MG401 |
F | LEU252 |
F | GLU256 |
F | ASP295 |
F | ARG299 |
site_id | BC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG E 401 |
Chain | Residue |
E | ASP238 |
E | 08T400 |
site_id | BC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 08T G 400 |
Chain | Residue |
G | MG401 |
H | ARG299 |
G | SER169 |
G | GLY170 |
G | GLY172 |
G | LYS173 |
G | GLU174 |
G | VAL175 |
G | ASP238 |
G | GLU239 |
G | LEU320 |
G | VAL356 |
G | ARG357 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG G 401 |
Chain | Residue |
G | GLU174 |
G | ASP238 |
G | 08T400 |
site_id | BC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 08T H 400 |
Chain | Residue |
H | GLY170 |
H | GLY172 |
H | LYS173 |
H | GLU174 |
H | ASP238 |
H | GLU239 |
H | ASN280 |
H | ARG313 |
H | VAL356 |
H | ARG357 |
H | MG401 |
I | GLU256 |
I | ARG299 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG H 401 |
Chain | Residue |
H | ASP238 |
H | GLU239 |
H | 08T400 |
site_id | BC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 08T I 400 |
Chain | Residue |
I | TYR139 |
I | SER169 |
I | GLY170 |
I | GLY172 |
I | LYS173 |
I | GLU174 |
I | GLU239 |
I | ASN280 |
I | VAL356 |
I | ARG357 |
I | MG401 |
J | GLU256 |
J | ARG299 |
site_id | BC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG I 401 |
Chain | Residue |
I | ASP238 |
I | 08T400 |
site_id | BC8 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 08T J 400 |
Chain | Residue |
J | TYR139 |
J | VAL140 |
J | SER169 |
J | GLY170 |
J | VAL171 |
J | GLY172 |
J | LYS173 |
J | GLU174 |
J | VAL175 |
J | GLU239 |
J | ASN280 |
J | LEU320 |
J | VAL356 |
J | ARG357 |
J | MG401 |
K | ARG299 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG J 401 |
Chain | Residue |
J | ASP238 |
J | GLU239 |
J | 08T400 |
site_id | CC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 08T K 400 |
Chain | Residue |
K | TYR139 |
K | VAL140 |
K | SER169 |
K | GLY170 |
K | VAL171 |
K | GLY172 |
K | LYS173 |
K | GLU174 |
K | ASP238 |
K | GLU239 |
K | ASN280 |
K | ARG313 |
K | VAL356 |
K | ARG357 |
K | MG401 |
L | ARG299 |
site_id | CC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG K 401 |
Chain | Residue |
K | ASP238 |
K | GLU239 |
K | 08T400 |
site_id | CC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE ADP L 400 |
Chain | Residue |
L | GLU138 |
L | SER169 |
L | GLY170 |
L | VAL171 |
L | GLY172 |
L | LYS173 |
L | GLU174 |
L | VAL175 |
L | ASP238 |
L | ASN280 |
L | LEU320 |
L | VAL356 |
L | ARG357 |
site_id | CC4 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 08T M 400 |
Chain | Residue |
M | TYR139 |
M | GLU168 |
M | SER169 |
M | GLY170 |
M | VAL171 |
M | GLY172 |
M | LYS173 |
M | GLU174 |
M | ASP238 |
M | GLU239 |
M | ASN280 |
M | VAL356 |
M | ARG357 |
M | LYS360 |
M | MG401 |
N | ARG299 |
site_id | CC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG M 401 |
Chain | Residue |
M | ASP238 |
M | 08T400 |
site_id | CC6 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE 08T N 400 |
Chain | Residue |
N | GLU168 |
N | SER169 |
N | GLY170 |
N | GLY172 |
N | LYS173 |
N | GLU174 |
N | VAL175 |
N | ASP238 |
N | GLU239 |
N | ASN280 |
N | LEU320 |
N | VAL356 |
N | ARG357 |
N | MG401 |
O | LEU252 |
O | GLU256 |
O | ASP295 |
O | ARG299 |
site_id | CC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG N 401 |
Chain | Residue |
N | ASP238 |
N | GLU239 |
N | 08T400 |
site_id | CC8 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 08T O 400 |
Chain | Residue |
O | SER169 |
O | GLY170 |
O | VAL171 |
O | GLY172 |
O | LYS173 |
O | GLU174 |
O | VAL175 |
O | ASP238 |
O | GLU239 |
O | ASN280 |
O | LEU320 |
O | PHE324 |
O | VAL356 |
O | ARG357 |
O | MG401 |
P | ARG299 |
site_id | CC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG O 401 |
Chain | Residue |
O | ASP238 |
O | 08T400 |
site_id | DC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 08T P 400 |
Chain | Residue |
P | VAL140 |
P | SER169 |
P | GLY170 |
P | VAL171 |
P | GLY172 |
P | LYS173 |
P | GLU174 |
P | GLU239 |
P | ASN280 |
P | VAL356 |
P | ARG357 |
P | MG401 |
Q | ARG299 |
site_id | DC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG P 401 |
Chain | Residue |
P | ASP238 |
P | 08T400 |
site_id | DC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 08T Q 400 |
Chain | Residue |
Q | TYR139 |
Q | SER169 |
Q | GLY170 |
Q | VAL171 |
Q | GLY172 |
Q | LYS173 |
Q | GLU174 |
Q | GLU239 |
Q | ASN280 |
Q | ARG313 |
Q | VAL356 |
Q | ARG357 |
Q | MG401 |
R | GLU256 |
R | ARG299 |
site_id | DC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG Q 401 |
Chain | Residue |
Q | ASP238 |
Q | GLU239 |
Q | 08T400 |
site_id | DC5 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 08T S 400 |
Chain | Residue |
S | TYR139 |
S | VAL140 |
S | PHE141 |
S | GLU168 |
S | SER169 |
S | GLY170 |
S | VAL171 |
S | GLY172 |
S | LYS173 |
S | GLU174 |
S | VAL175 |
S | ASP238 |
S | GLU239 |
S | ASN280 |
S | LEU320 |
S | PHE324 |
S | VAL356 |
S | ARG357 |
S | LYS360 |
S | MG401 |
T | ARG299 |
site_id | DC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG S 401 |
Chain | Residue |
S | ASP238 |
S | 08T400 |
site_id | DC7 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 08T T 400 |
Chain | Residue |
T | GLU168 |
T | SER169 |
T | GLY170 |
T | GLY172 |
T | LYS173 |
T | GLU174 |
T | VAL175 |
T | ASP238 |
T | GLU239 |
T | ARG313 |
T | VAL356 |
T | ARG357 |
T | MG401 |
U | GLU256 |
U | ASP295 |
U | ARG299 |
site_id | DC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG T 401 |
Chain | Residue |
T | ASP238 |
T | 08T400 |
U | ARG299 |
site_id | DC9 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 08T U 400 |
Chain | Residue |
U | SER169 |
U | GLY170 |
U | VAL171 |
U | GLY172 |
U | LYS173 |
U | GLU174 |
U | VAL175 |
U | ASN280 |
U | ARG313 |
U | VAL356 |
U | ARG357 |
U | MG401 |
V | ARG299 |
site_id | EC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG U 401 |
Chain | Residue |
U | LYS173 |
U | ASN280 |
U | 08T400 |
site_id | EC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 08T V 400 |
Chain | Residue |
V | TYR139 |
V | SER169 |
V | GLY170 |
V | VAL171 |
V | GLY172 |
V | LYS173 |
V | GLU174 |
V | VAL175 |
V | GLU239 |
V | ASN280 |
V | VAL356 |
V | ARG357 |
V | MG401 |
W | ARG299 |
site_id | EC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG V 401 |
Chain | Residue |
V | ASP238 |
V | GLU239 |
V | 08T400 |
W | ARG299 |
site_id | EC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 08T W 400 |
Chain | Residue |
W | TYR139 |
W | SER169 |
W | GLY170 |
W | VAL171 |
W | GLY172 |
W | LYS173 |
W | GLU174 |
W | ASP238 |
W | GLU239 |
W | ASN280 |
W | ARG313 |
W | VAL356 |
W | ARG357 |
W | MG401 |
X | ARG299 |
site_id | EC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG W 401 |
Chain | Residue |
W | ASP238 |
W | GLU239 |
W | 08T400 |
site_id | EC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE ADP X 400 |
Chain | Residue |
X | SER169 |
X | GLY170 |
X | VAL171 |
X | GLY172 |
X | LYS173 |
X | GLU174 |
X | VAL175 |
X | GLU239 |
X | LEU320 |
X | VAL356 |
X | ARG357 |
Functional Information from PROSITE/UniProt
site_id | PS00675 |
Number of Residues | 14 |
Details | SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VLItGESGVGKevV |
Chain | Residue | Details |
A | VAL163-VAL176 |
site_id | PS00676 |
Number of Residues | 16 |
Details | SIGMA54_INTERACT_2 Sigma-54 interaction domain ATP-binding region B signature. GfFelADGGTLFLDEI |
Chain | Residue | Details |
A | GLY225-ILE240 |