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4L6P

Structure of C22Y Mutant PCNA protein defective in DNA mismatch repair

Functional Information from GO Data
ChainGOidnamespacecontents
A0000278biological_processmitotic cell cycle
A0000710biological_processmeiotic mismatch repair
A0000781cellular_componentchromosome, telomeric region
A0003677molecular_functionDNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005657cellular_componentreplication fork
A0006260biological_processDNA replication
A0006272biological_processleading strand elongation
A0006273biological_processlagging strand elongation
A0006275biological_processregulation of DNA replication
A0006281biological_processDNA repair
A0006289biological_processnucleotide-excision repair
A0006298biological_processmismatch repair
A0006301biological_processpostreplication repair
A0007064biological_processmitotic sister chromatid cohesion
A0019985biological_processtranslesion synthesis
A0030337molecular_functionDNA polymerase processivity factor activity
A0030466biological_processsilent mating-type cassette heterochromatin formation
A0031509biological_processsubtelomeric heterochromatin formation
A0034087biological_processestablishment of mitotic sister chromatid cohesion
A0035753biological_processmaintenance of DNA trinucleotide repeats
A0042802molecular_functionidentical protein binding
A0043626cellular_componentPCNA complex
A0045739biological_processpositive regulation of DNA repair
A0045740biological_processpositive regulation of DNA replication
A0051054biological_processpositive regulation of DNA metabolic process
A0070987biological_processerror-free translesion synthesis
B0000278biological_processmitotic cell cycle
B0000710biological_processmeiotic mismatch repair
B0000781cellular_componentchromosome, telomeric region
B0003677molecular_functionDNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005657cellular_componentreplication fork
B0006260biological_processDNA replication
B0006272biological_processleading strand elongation
B0006273biological_processlagging strand elongation
B0006275biological_processregulation of DNA replication
B0006281biological_processDNA repair
B0006289biological_processnucleotide-excision repair
B0006298biological_processmismatch repair
B0006301biological_processpostreplication repair
B0007064biological_processmitotic sister chromatid cohesion
B0019985biological_processtranslesion synthesis
B0030337molecular_functionDNA polymerase processivity factor activity
B0030466biological_processsilent mating-type cassette heterochromatin formation
B0031509biological_processsubtelomeric heterochromatin formation
B0034087biological_processestablishment of mitotic sister chromatid cohesion
B0035753biological_processmaintenance of DNA trinucleotide repeats
B0042802molecular_functionidentical protein binding
B0043626cellular_componentPCNA complex
B0045739biological_processpositive regulation of DNA repair
B0045740biological_processpositive regulation of DNA replication
B0051054biological_processpositive regulation of DNA metabolic process
B0070987biological_processerror-free translesion synthesis
C0000278biological_processmitotic cell cycle
C0000710biological_processmeiotic mismatch repair
C0000781cellular_componentchromosome, telomeric region
C0003677molecular_functionDNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005657cellular_componentreplication fork
C0006260biological_processDNA replication
C0006272biological_processleading strand elongation
C0006273biological_processlagging strand elongation
C0006275biological_processregulation of DNA replication
C0006281biological_processDNA repair
C0006289biological_processnucleotide-excision repair
C0006298biological_processmismatch repair
C0006301biological_processpostreplication repair
C0007064biological_processmitotic sister chromatid cohesion
C0019985biological_processtranslesion synthesis
C0030337molecular_functionDNA polymerase processivity factor activity
C0030466biological_processsilent mating-type cassette heterochromatin formation
C0031509biological_processsubtelomeric heterochromatin formation
C0034087biological_processestablishment of mitotic sister chromatid cohesion
C0035753biological_processmaintenance of DNA trinucleotide repeats
C0042802molecular_functionidentical protein binding
C0043626cellular_componentPCNA complex
C0045739biological_processpositive regulation of DNA repair
C0045740biological_processpositive regulation of DNA replication
C0051054biological_processpositive regulation of DNA metabolic process
C0070987biological_processerror-free translesion synthesis
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL C 301
ChainResidue
CARG14
CASN84
CHOH401

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL C 302
ChainResidue
CGLN58
CLYS210

Functional Information from PROSITE/UniProt
site_idPS00293
Number of Residues19
DetailsPCNA_2 Proliferating cell nuclear antigen signature 2. RCDHpvtLgmdLtSLsKIL
ChainResidueDetails
AARG61-LEU79

site_idPS01251
Number of Residues24
DetailsPCNA_1 Proliferating cell nuclear antigen signature 1. GIiAqAVDdSRVlLVsLeIgveaF
ChainResidueDetails
AGLY34-PHE57

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues57
DetailsDNA_BIND: DNA_BIND => ECO:0000255
ChainResidueDetails
AARG61-ARG80
BARG61-ARG80
CARG61-ARG80

site_idSWS_FT_FI2
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:15166219
ChainResidueDetails
ALYS127
BLYS127
CLYS127

site_idSWS_FT_FI3
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:12226657
ChainResidueDetails
BLYS164
CLYS164
ALYS164

219869

PDB entries from 2024-05-15

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