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4K80

Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 2:0 ceramide-1-phosphate (2:0-C1P)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005543molecular_functionphospholipid binding
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0008289molecular_functionlipid binding
A0010008cellular_componentendosome membrane
A0010507biological_processnegative regulation of autophagy
A0032691biological_processnegative regulation of interleukin-1 beta production
A0035627biological_processceramide transport
A0046836biological_processglycolipid transport
A0120009biological_processintermembrane lipid transfer
A0120013molecular_functionlipid transfer activity
A1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
A1902387molecular_functionceramide 1-phosphate binding
A1902388molecular_functionceramide 1-phosphate transfer activity
A1902389biological_processceramide 1-phosphate transport
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE 1PW A 301
ChainResidue
APHE52
APHE121
ACYS138
ALEU146
AHIS150
AHOH408
AHOH436
AHOH494
AHOH507
AHOH614
AHOH615
AILE53
ALYS55
AASP56
AVAL57
ALYS60
AARG106
AARG110
ATRP117

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:23863933
ChainResidueDetails
AASP56
ALYS60
AARG106
AARG110
AHIS150

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PDB entries from 2024-05-01

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