4I56
HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| A | 0005778 | cellular_component | peroxisomal membrane |
| A | 0006696 | biological_process | ergosterol biosynthetic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
| B | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| B | 0005778 | cellular_component | peroxisomal membrane |
| B | 0006696 | biological_process | ergosterol biosynthetic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0015936 | biological_process | coenzyme A metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE 1CZ A 501 |
| Chain | Residue |
| A | ARG11 |
| A | ASN271 |
| A | GLY367 |
| A | ALA368 |
| A | GOL503 |
| A | HOH601 |
| A | HOH622 |
| A | HOH638 |
| A | HOH654 |
| A | HOH675 |
| A | HOH733 |
| A | GLU83 |
| A | HOH736 |
| A | HOH902 |
| A | HOH924 |
| A | HOH964 |
| B | GLU552 |
| B | ASN553 |
| B | ILE713 |
| A | SER85 |
| A | ALA88 |
| A | TYR92 |
| A | LYS95 |
| A | ARG261 |
| A | THR264 |
| A | GLY268 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | ALA184 |
| A | MET185 |
| A | GLY186 |
| A | ALA187 |
| A | ASN188 |
| A | THR189 |
| A | GLY329 |
| A | HOH635 |
| A | HOH717 |
| A | HOH823 |
| A | HOH877 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | GLU83 |
| A | LYS267 |
| A | ASN271 |
| A | 1CZ501 |
| A | HOH638 |
| A | HOH736 |
| B | ALA687 |
| B | ASN716 |
| B | HOH1320 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 504 |
| Chain | Residue |
| A | GLU375 |
| B | HOH1233 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1001 |
| Chain | Residue |
| B | ALA684 |
| B | MET685 |
| B | GLY686 |
| B | ALA687 |
| B | ASN688 |
| B | HOH1105 |
| B | HOH1160 |
| B | HOH1183 |
| B | HOH1221 |
| B | HOH1285 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 1002 |
| Chain | Residue |
| A | ASN216 |
| B | GLU583 |
| B | LYS767 |
| B | ASN771 |
| B | HOH1166 |
| B | HOH1391 |
| B | HOH1413 |
| B | HOH1414 |
| B | HOH1456 |
Functional Information from PROSITE/UniProt
| site_id | PS00066 |
| Number of Residues | 15 |
| Details | HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. HlIVdVRDaMGaNtV |
| Chain | Residue | Details |
| A | HIS176-VAL190 |
| site_id | PS00318 |
| Number of Residues | 8 |
| Details | HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGlVGGAT |
| Chain | Residue | Details |
| A | VAL325-THR332 |
| site_id | PS01192 |
| Number of Residues | 14 |
| Details | HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALaTegIqRGHMaL |
| Chain | Residue | Details |
| A | ALA371-LEU384 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | GLU83 | |
| A | LYS267 | |
| A | ASP283 | |
| B | GLU583 | |
| B | LYS767 | |
| B | ASP783 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10003, ECO:0000269|PubMed:1634543 |
| Chain | Residue | Details |
| A | HIS381 | |
| B | HIS881 |
