4I56

HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa

Summary for 4I56

• Entry DOI: 10.2210/pdb4i56/pdb
• Related: 1QAX 1QAY 1R31 1R7I 4I4B 4I64 4I6A 4I6W 4I6Y
• Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Pseudomonas mevalonii
• Total number of polymer chains: 2
• Total formula weight: 92678.62

Authors

Steussy, C.N.,Stauffacher, C.V.,Schmidt, T.,Crichelow, C.J.,Rodwell, V.W.,Wrensford, L.V.,Min, J.,Burgner II, J.W. (deposition date: 2012-11-28, release date: 2013-07-17, Last modification date: 2019-07-17)

• Primary citation: Steussy, C.N.,Critchelow, C.J.,Schmidt, T.,Min, J.K.,Wrensford, L.V.,Burgner, J.W.,Rodwell, V.W.,Stauffacher, C.V.; A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.; Biochemistry, 52:5195-5205, 2013; PubMed: 23802607; DOI: 10.1021/bi400335g

Experimental method

X-RAY DIFFRACTION (1.5 Å)