4I4W
Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement
Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0000139 | cellular_component | Golgi membrane |
B | 0001913 | biological_process | T cell mediated cytotoxicity |
B | 0001916 | biological_process | positive regulation of T cell mediated cytotoxicity |
B | 0002237 | biological_process | response to molecule of bacterial origin |
B | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
B | 0002481 | biological_process | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
B | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
B | 0002726 | biological_process | positive regulation of T cell cytokine production |
B | 0005198 | molecular_function | structural molecule activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005765 | cellular_component | lysosomal membrane |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005788 | cellular_component | endoplasmic reticulum lumen |
B | 0005794 | cellular_component | Golgi apparatus |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0005925 | cellular_component | focal adhesion |
B | 0006826 | biological_process | iron ion transport |
B | 0006879 | biological_process | intracellular iron ion homeostasis |
B | 0006955 | biological_process | immune response |
B | 0007608 | biological_process | sensory perception of smell |
B | 0007611 | biological_process | learning or memory |
B | 0009897 | cellular_component | external side of plasma membrane |
B | 0009986 | cellular_component | cell surface |
B | 0010977 | biological_process | negative regulation of neuron projection development |
B | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
B | 0016020 | cellular_component | membrane |
B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
B | 0023026 | molecular_function | MHC class II protein complex binding |
B | 0030670 | cellular_component | phagocytic vesicle membrane |
B | 0031901 | cellular_component | early endosome membrane |
B | 0031902 | cellular_component | late endosome membrane |
B | 0031905 | cellular_component | early endosome lumen |
B | 0032092 | biological_process | positive regulation of protein binding |
B | 0033077 | biological_process | T cell differentiation in thymus |
B | 0034756 | biological_process | regulation of iron ion transport |
B | 0035580 | cellular_component | specific granule lumen |
B | 0042026 | biological_process | protein refolding |
B | 0042605 | molecular_function | peptide antigen binding |
B | 0042612 | cellular_component | MHC class I protein complex |
B | 0042613 | cellular_component | MHC class II protein complex |
B | 0042802 | molecular_function | identical protein binding |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0042824 | cellular_component | MHC class I peptide loading complex |
B | 0045646 | biological_process | regulation of erythrocyte differentiation |
B | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
B | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
B | 0050768 | biological_process | negative regulation of neurogenesis |
B | 0050778 | biological_process | positive regulation of immune response |
B | 0050870 | biological_process | positive regulation of T cell activation |
B | 0051289 | biological_process | protein homotetramerization |
B | 0055038 | cellular_component | recycling endosome membrane |
B | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
B | 0070062 | cellular_component | extracellular exosome |
B | 0071281 | biological_process | cellular response to iron ion |
B | 0071283 | biological_process | cellular response to iron(III) ion |
B | 0071316 | biological_process | cellular response to nicotine |
B | 1900121 | biological_process | negative regulation of receptor binding |
B | 1900122 | biological_process | positive regulation of receptor binding |
B | 1904434 | biological_process | positive regulation of ferrous iron binding |
B | 1904437 | biological_process | positive regulation of transferrin receptor binding |
B | 1904724 | cellular_component | tertiary granule lumen |
B | 1990000 | biological_process | amyloid fibril formation |
B | 1990712 | cellular_component | HFE-transferrin receptor complex |
B | 2000774 | biological_process | positive regulation of cellular senescence |
B | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 301 |
Chain | Residue |
A | ASP29 |
A | ASP30 |
A | HOH592 |
B | HOH224 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 302 |
Chain | Residue |
B | EDO102 |
A | HIS188 |
A | THR190 |
A | TRP204 |
B | ARG97 |
B | ASP98 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 303 |
Chain | Residue |
A | ARG17 |
A | LYS121 |
A | EDO312 |
A | HOH565 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 304 |
Chain | Residue |
A | HIS151 |
A | HIS192 |
B | ASP96 |
B | ASP98 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 305 |
Chain | Residue |
A | PRO20 |
A | ARG21 |
A | SER38 |
A | ASP39 |
A | HOH574 |
B | MET0 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 306 |
Chain | Residue |
A | TYR85 |
A | LYS121 |
A | ASP122 |
A | ASP137 |
A | HOH527 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 307 |
Chain | Residue |
A | TRP274 |
A | GLU275 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 308 |
Chain | Residue |
A | VAL76 |
A | THR80 |
A | HOH608 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 309 |
Chain | Residue |
A | GLU55 |
A | GLY56 |
A | PRO57 |
A | TRP60 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 310 |
Chain | Residue |
A | TRP107 |
A | LYS176 |
A | GLN180 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 311 |
Chain | Residue |
A | ASP122 |
A | HOH517 |
A | HOH526 |
A | HOH535 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 312 |
Chain | Residue |
A | SER13 |
A | ARG14 |
A | ARG17 |
A | SER92 |
A | EDO303 |
A | HOH449 |
A | HOH564 |
B | ASP34 |
site_id | BC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 313 |
Chain | Residue |
A | ARG35 |
A | ALA40 |
A | ALA41 |
A | SER88 |
A | GOL314 |
A | HOH444 |
A | HOH545 |
site_id | BC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 314 |
Chain | Residue |
A | ALA41 |
A | GLN87 |
A | SER88 |
A | HIS93 |
A | GOL313 |
A | HOH421 |
A | HOH594 |
site_id | BC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 315 |
Chain | Residue |
A | GLY16 |
A | ARG17 |
A | GLY18 |
A | HOH484 |
A | HOH534 |
B | ARG3 |
B | HOH238 |
B | HOH271 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 316 |
Chain | Residue |
A | ARG219 |
A | ARG256 |
A | HOH614 |
B | LYS19 |
B | SER20 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 317 |
Chain | Residue |
A | ARG21 |
A | HOH578 |
B | HOH243 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 101 |
Chain | Residue |
A | GLN115 |
B | SER57 |
B | LYS58 |
B | TRP60 |
site_id | CC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE EDO B 102 |
Chain | Residue |
A | LEU206 |
A | ARG234 |
A | GLN242 |
A | EDO302 |
B | TYR10 |
B | SER11 |
B | HIS13 |
B | PRO14 |
B | HOH256 |
B | HOH265 |
site_id | CC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 103 |
Chain | Residue |
B | VAL9 |
B | MET99 |
B | HOH211 |
B | HOH242 |
B | HOH283 |
A | ARG234 |
B | GLN8 |
site_id | CC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 104 |
Chain | Residue |
B | TRP95 |
B | ASP96 |
site_id | CC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO B 105 |
Chain | Residue |
B | LYS6 |
B | ILE7 |
B | HOH299 |
site_id | CC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 106 |
Chain | Residue |
B | ASP34 |
B | GLU36 |
Functional Information from PROSITE/UniProt
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH |
Chain | Residue | Details |
B | TYR78-HIS84 | |
A | TYR257-HIS263 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 |
Chain | Residue | Details |
B | GLN2 | |
A | THR73 | |
A | TYR84 | |
A | THR143 | |
A | LYS146 | |
A | TYR171 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443 |
Chain | Residue | Details |
B | ILE1 | |
A | TYR159 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 |
Chain | Residue | Details |
B | LYS19 | |
B | LYS41 | |
B | LYS48 | |
B | LYS58 | |
B | LYS91 | |
B | LYS94 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
A | ASN86 |