4GGD

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0010997	molecular_function	anaphase-promoting complex binding
A	0097027	molecular_function	ubiquitin-protein transferase activator activity
A	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
B	0010997	molecular_function	anaphase-promoting complex binding
B	0097027	molecular_function	ubiquitin-protein transferase activator activity
B	1904668	biological_process	positive regulation of ubiquitin protein ligase activity

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. TGGGtsDrHIRIWNV

Chain	Residue	Details
A	THR373-VAL387

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15525512

Chain	Residue	Details
A	SER72
A	SER92
A	SER153
A	SER161
B	SER72
B	SER92
B	SER153
B	SER161

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:14657031

Chain	Residue	Details
A	THR106
B	THR106

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:15525512

Chain	Residue	Details
A	THR157
B	THR157

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site_id	SWS_FT_FI4
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21926987

Chain	Residue	Details
A	LYS485
A	LYS490
B	LYS485
B	LYS490

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