4AXD
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with AMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0010264 | biological_process | myo-inositol hexakisphosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0030643 | biological_process | intracellular phosphate ion homeostasis |
| A | 0032942 | molecular_function | inositol tetrakisphosphate 2-kinase activity |
| A | 0035299 | molecular_function | inositol pentakisphosphate 2-kinase activity |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048527 | biological_process | lateral root development |
| A | 0050832 | biological_process | defense response to fungus |
| A | 0051607 | biological_process | defense response to virus |
| A | 0055062 | biological_process | phosphate ion homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ANP A 600 |
| Chain | Residue |
| A | GLU18 |
| A | ASP148 |
| A | HIS149 |
| A | GLU166 |
| A | PHE243 |
| A | MET372 |
| A | ASP407 |
| A | HOH2018 |
| A | HOH2021 |
| A | HOH2024 |
| A | HOH2027 |
| A | GLY19 |
| A | HOH2036 |
| A | HOH2213 |
| A | HOH2290 |
| A | HOH2306 |
| A | GLY20 |
| A | ALA21 |
| A | ASN22 |
| A | VAL24 |
| A | VAL38 |
| A | ARG40 |
| A | ASN147 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 700 |
| Chain | Residue |
| A | HIS320 |
| A | CYS330 |
| A | CYS333 |
| A | HIS346 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1435 |
| Chain | Residue |
| A | GLU18 |
| A | ARG130 |
| A | ARG241 |
| A | GLY254 |
| A | HOH2021 |
| A | HOH2214 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1436 |
| Chain | Residue |
| A | LYS170 |
| A | ARG192 |
| A | HIS196 |
| A | LEU422 |
| A | HOH2320 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1437 |
| Chain | Residue |
| A | ASN53 |
| A | SER54 |
| A | SER63 |
| A | SER63 |
| A | HOH2051 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1438 |
| Chain | Residue |
| A | GLY98 |
| A | PRO99 |
| A | LYS100 |
| A | TYR203 |
| A | ARG303 |
| A | LYS425 |
| A | HOH2081 |
| A | HOH2087 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1439 |
| Chain | Residue |
| A | LYS168 |
| A | LYS170 |
| A | ASN238 |
| A | GLU255 |
| A | HOH2171 |
| A | HOH2212 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CIT A 1440 |
| Chain | Residue |
| A | ASN147 |
| A | ASP148 |
| A | HIS149 |
| A | LEU151 |
| A | PHE152 |
| A | SER374 |
| A | LYS402 |
| A | HIS404 |
| A | HOH2127 |
| A | HOH2291 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:20453199, ECO:0000305|PubMed:22745128 |
| Chain | Residue | Details |
| A | GLU166 | |
| A | ASP407 | |
| A | GLY19 | |
| A | ARG40 | |
| A | ASN147 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:20453199, ECO:0000305|PubMed:22362712, ECO:0000305|PubMed:22684075, ECO:0000305|PubMed:22745128 |
| Chain | Residue | Details |
| A | ARG130 | |
| A | LYS170 | |
| A | LYS200 | |
| A | ASN238 | |
| A | ASP368 | |
| A | LYS411 | |
| A | ARG415 | |
| A | TYR419 | |
| A | ARG45 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:22745128 |
| Chain | Residue | Details |
| A | ARG241 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2XAL, ECO:0007744|PDB:2XAM, ECO:0007744|PDB:2XAN, ECO:0007744|PDB:2XAO, ECO:0007744|PDB:2XAR, ECO:0007744|PDB:3UDT, ECO:0007744|PDB:3UDZ, ECO:0007744|PDB:4AQK, ECO:0007744|PDB:4AXC, ECO:0007744|PDB:4AXD, ECO:0007744|PDB:4AXE, ECO:0007744|PDB:4AXF, ECO:0007744|PDB:4LV7 |
| Chain | Residue | Details |
| A | CYS330 | |
| A | HIS346 | |
| A | HIS320 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2XAL, ECO:0007744|PDB:2XAM, ECO:0007744|PDB:2XAN, ECO:0007744|PDB:2XAO, ECO:0007744|PDB:2XAR, ECO:0007744|PDB:3UDT, ECO:0007744|PDB:4AQK, ECO:0007744|PDB:4AXC, ECO:0007744|PDB:4AXD, ECO:0007744|PDB:4AXE, ECO:0007744|PDB:4AXF, ECO:0007744|PDB:4LV7 |
| Chain | Residue | Details |
| A | CYS333 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | MET1 |
