4AHC

Crystal Structure of an Evolved Replicating DNA Polymerase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0004519	molecular_function	endonuclease activity
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006287	biological_process	base-excision repair, gap-filling
A	0006297	biological_process	nucleotide-excision repair, DNA gap filling
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0009432	biological_process	SOS response
A	0045004	biological_process	DNA replication proofreading
A	0071897	biological_process	DNA biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0004519	molecular_function	endonuclease activity
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006287	biological_process	base-excision repair, gap-filling
B	0006297	biological_process	nucleotide-excision repair, DNA gap filling
B	0008296	molecular_function	3'-5'-DNA exonuclease activity
B	0009432	biological_process	SOS response
B	0045004	biological_process	DNA replication proofreading
B	0071897	biological_process	DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 800

Chain	Residue
A	ASP4
A	GLN242
A	GLU251
A	PRO340
A	ASP343

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 801

Chain	Residue
A	HIS546
A	TYR584
A	TYR595

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 800

Chain	Residue
B	VAL5
B	GLU251
B	TRP342
B	ASP4

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 801

Chain	Residue
B	TYR403
B	HIS546
B	TYR584
B	TYR595
B	ILE605

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Functional Information from PROSITE/UniProt

site_id	PS00116
Number of Residues	9
Details	DNA_POLYMERASE_B DNA polymerase family B signature. YIDTDGLHA

Chain	Residue	Details
A	TYR539-ALA547

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