3VM8

Crystal structure of the human APOBEC3C having HIV-1 Vif-binding interface

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0009972	biological_process	cytidine deamination
A	0010526	biological_process	retrotransposon silencing
A	0016554	biological_process	cytidine to uridine editing
A	0016787	molecular_function	hydrolase activity
A	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
A	0046872	molecular_function	metal ion binding
A	0047844	molecular_function	deoxycytidine deaminase activity
A	0051607	biological_process	defense response to virus
A	0070383	biological_process	DNA cytosine deamination
A	0080111	biological_process	DNA demethylation
B	0000932	cellular_component	P-body
B	0002376	biological_process	immune system process
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0004126	molecular_function	cytidine deaminase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0008270	molecular_function	zinc ion binding
B	0009972	biological_process	cytidine deamination
B	0010526	biological_process	retrotransposon silencing
B	0016554	biological_process	cytidine to uridine editing
B	0016787	molecular_function	hydrolase activity
B	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
B	0044355	biological_process	clearance of foreign intracellular DNA
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
B	0046872	molecular_function	metal ion binding
B	0047844	molecular_function	deoxycytidine deaminase activity
B	0051607	biological_process	defense response to virus
B	0070383	biological_process	DNA cytosine deamination
B	0080111	biological_process	DNA demethylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	HIS66
A	CYS97
A	CYS100

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 202

Chain	Residue
B	HIS66
B	GLU68
B	CYS97
B	CYS100

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Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAErcFLswfcddilspntkyqvtwytsws..........PCpd......CageV

Chain	Residue	Details
A	HIS66-VAL104

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01083

Chain	Residue	Details
A	GLU68
B	GLU68

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0007744|PDB:3VM8, ECO:0007744|PDB:3VOW

Chain	Residue	Details
A	HIS66
A	CYS97
A	CYS100
B	HIS66
B	CYS97
B	CYS100

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