Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0035899 | biological_process | suppression of blood coagulation in another organism |
| C | 0090729 | molecular_function | toxin activity |
| D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0035899 | biological_process | suppression of blood coagulation in another organism |
| D | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 801 |
| Chain | Residue |
| B | ARG712 |
| B | TYR713 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 101 |
| Chain | Residue |
| D | THR49 |
| D | LYS50 |
| D | GLU51 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU599-CYS604 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV |
| Chain | Residue | Details |
| A | ASP735-VAL746 | |
| site_id | PS00280 |
| Number of Residues | 19 |
| Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FiyGGCegnannFitkeeC |
| Chain | Residue | Details |
| C | PHE35-CYS53 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Reactive bond for trypsin => ECO:0000250 |
| Chain | Residue | Details |
| C | ARG17 | |
| D | ARG17 | |
| A | SER741 | |
| B | HIS603 | |
| B | ASP646 | |
| B | SER741 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by plasminogen activator |
| Chain | Residue | Details |
| A | ARG561 | |
| B | ARG561 | |
| Chain | Residue | Details |
| A | SER578 | |
| B | SER578 | |
| Chain | Residue | Details |
| A | SER669 | |
| B | SER669 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| A | HIS603 | proton shuttle (general acid/base) |
| A | ASP646 | electrostatic stabiliser, modifies pKa |
| A | SER741 | covalent catalysis, proton shuttle (general acid/base) |
| A | GLY742 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| B | HIS603 | proton shuttle (general acid/base) |
| B | ASP646 | electrostatic stabiliser, modifies pKa |
| B | SER741 | covalent catalysis, proton shuttle (general acid/base) |
| B | GLY742 | electrostatic stabiliser |
