Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE UBS A 317 |
Chain | Residue |
A | TYR106 |
A | GLU166 |
A | LEU202 |
A | ARG203 |
A | HIS231 |
A | DMS318 |
A | DMS318 |
A | GOL323 |
A | ZN326 |
A | HOH549 |
A | HOH570 |
A | ASN112 |
A | HOH614 |
A | ALA113 |
A | PHE114 |
A | TRP115 |
A | HIS142 |
A | GLU143 |
A | HIS146 |
A | TYR157 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DMS A 318 |
Chain | Residue |
A | TYR110 |
A | ASN112 |
A | PHE114 |
A | UBS317 |
A | UBS317 |
A | GOL324 |
A | HOH373 |
A | HOH505 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 319 |
Chain | Residue |
A | HIS216 |
A | SER218 |
A | TYR251 |
A | HOH604 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS A 320 |
Chain | Residue |
A | GLY95 |
A | PRO184 |
A | TRP186 |
A | HOH510 |
A | HOH520 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS A 321 |
Chain | Residue |
A | GLY3 |
A | TYR24 |
A | TYR24 |
A | SER25 |
A | TYR28 |
A | HOH593 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS A 322 |
Chain | Residue |
A | ILE1 |
A | THR2 |
A | GLY3 |
A | GLN31 |
A | ASN33 |
site_id | AC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 323 |
Chain | Residue |
A | PHE114 |
A | TRP115 |
A | HIS146 |
A | TYR157 |
A | UBS317 |
A | HOH442 |
A | HOH450 |
A | HOH489 |
site_id | AC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 324 |
Chain | Residue |
A | GLY109 |
A | TYR110 |
A | ASN111 |
A | ASN112 |
A | GLN158 |
A | DMS318 |
A | HOH617 |
A | HOH625 |
site_id | AC9 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE GOL A 325 |
Chain | Residue |
A | THR152 |
A | GLY247 |
A | GLY248 |
A | VAL255 |
A | GLN273 |
A | TYR274 |
A | LEU275 |
A | HOH487 |
A | HOH526 |
A | HOH552 |
A | HOH563 |
A | HOH680 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 326 |
Chain | Residue |
A | HIS142 |
A | HIS146 |
A | GLU166 |
A | UBS317 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 327 |
Chain | Residue |
A | ASP138 |
A | GLU177 |
A | ASP185 |
A | GLU187 |
A | GLU190 |
A | HOH720 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 328 |
Chain | Residue |
A | GLU177 |
A | ASN183 |
A | ASP185 |
A | GLU190 |
A | HOH726 |
A | HOH727 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 329 |
Chain | Residue |
A | TYR193 |
A | THR194 |
A | ILE197 |
A | ASP200 |
A | HOH721 |
A | HOH728 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 330 |
Chain | Residue |
A | ASP59 |
A | GLN61 |
A | HOH722 |
A | HOH723 |
A | HOH724 |
A | ASP57 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
Chain | Residue | Details |
A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU143 | |
Chain | Residue | Details |
A | HIS231 | |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP57 | |
A | ASP185 | |
A | GLU187 | |
A | GLU190 | |
A | TYR193 | |
A | THR194 | |
A | ILE197 | |
A | ASP200 | |
A | ASP59 | |
A | GLN61 | |
A | ASP138 | |
A | HIS142 | |
A | HIS146 | |
A | GLU166 | |
A | GLU177 | |
A | ASN183 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 176 |
Chain | Residue | Details |
A | HIS142 | metal ligand |
A | GLU143 | electrostatic stabiliser, metal ligand |
A | HIS146 | metal ligand |
A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
A | GLU166 | metal ligand |
A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |