3QBC

Structure and design of a new pterin site inhibitor of S. aureus HPPK

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
A	0005524	molecular_function	ATP binding
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0016301	molecular_function	kinase activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process
B	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
B	0005524	molecular_function	ATP binding
B	0009396	biological_process	folic acid-containing compound biosynthetic process
B	0016301	molecular_function	kinase activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046656	biological_process	folic acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE B55 A 159

Chain	Residue
A	THR43
A	ALA44
A	VAL46
A	PHE54
A	ASN56
A	PHE123
A	HOH268
B	PRO109
B	LYS110

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site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE B55 B 163

Chain	Residue
A	PRO109
A	LYS110
B	THR43
B	ALA44
B	VAL46
B	PHE54
B	ASN56
B	PHE123
B	HOH211
B	HOH249

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Functional Information from PROSITE/UniProt

site_id	PS00794
Number of Residues	12
Details	HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDVDIL

Chain	Residue	Details
A	ARG88-LEU99

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