3OS5
SET7/9-Dnmt1 K142me1 complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME A 500 |
| Chain | Residue |
| A | ASP194 |
| A | LYS195 |
| A | CYS200 |
| A | SER202 |
| A | GLU272 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 391 |
| Chain | Residue |
| A | ASN302 |
| A | ARG323 |
| A | HOH15 |
| A | HOH50 |
| A | THR300 |
| A | PRO301 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 392 |
| Chain | Residue |
| A | TYR217 |
| A | GLU220 |
| A | PHE231 |
| A | HOH381 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 393 |
| Chain | Residue |
| A | HOH74 |
| A | GLU228 |
| A | ASN282 |
| A | HIS283 |
| A | LYS294 |
| A | SAH1501 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 394 |
| Chain | Residue |
| A | TRP120 |
| A | TYR122 |
| A | TYR122 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 395 |
| Chain | Residue |
| A | GLU163 |
| A | ASP256 |
| B | PRO138 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SAH A 1501 |
| Chain | Residue |
| A | HOH14 |
| A | HOH36 |
| A | HOH52 |
| A | HOH74 |
| A | ALA226 |
| A | GLU228 |
| A | ASN265 |
| A | HIS293 |
| A | LYS294 |
| A | ASN296 |
| A | HIS297 |
| A | TYR335 |
| A | TRP352 |
| A | GLU356 |
| A | EDO393 |
| B | MLZ142 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855 |
| Chain | Residue | Details |
| A | ALA226 | |
| A | ASN296 | |
| A | HIS297 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855 |
| Chain | Residue | Details |
| A | GLU356 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | SITE: Histone H3K4 binding => ECO:0000269|PubMed:12540855 |
| Chain | Residue | Details |
| A | TYR245 | |
| A | ASP256 | |
| A | THR266 | |
| A | LYS317 | |
| A | TYR335 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 350 |
| Chain | Residue | Details |
| A | TYR245 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | HIS293 | electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS297 | electrostatic stabiliser, hydrogen bond acceptor |
| A | TYR305 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | TYR335 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
