3OF8

Structural Basis for Reversible and Irreversible Inhibition of Human Cathepsin L by their Respective Dipeptidyl Glyoxal and Diazomethylketone Inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE I0Y A 501

Chain	Residue
A	ARG9
A	LEU70
A	MET71
A	ALA136
A	ASP163
A	HIS164
A	TRP190
A	GLU192
A	GLU10
A	GLN20
A	CYS26
A	TRP27
A	GLY62
A	GLU64
A	GLY68
A	GLY69

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Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSA

Chain	Residue	Details
A	GLN20-ALA31

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site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG

Chain	Residue	Details
A	MET162-GLY172

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site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM

Chain	Residue	Details
A	TYR183-MET202

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:9468501

Chain	Residue	Details
A	CYS26

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	HIS164
A	ASN188

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:9468501

Chain	Residue	Details
A	GLU1

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN109

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