3OF8
Structural Basis for Reversible and Irreversible Inhibition of Human Cathepsin L by their Respective Dipeptidyl Glyoxal and Diazomethylketone Inhibitors
Summary for 3OF8
| Entry DOI | 10.2210/pdb3of8/pdb |
| Related | 3OF9 |
| Related PRD ID | PRD_000782 |
| Descriptor | Cathepsin L1, Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-(4-tert-butoxyphenyl)-4-hydroxy-3-oxobutan-2-yl]-L-phenylalaninamide (3 entities in total) |
| Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 24853.44 |
| Authors | Shenoy, R.T.,Sivaraman, J. (deposition date: 2010-08-14, release date: 2010-12-08, Last modification date: 2023-09-06) |
| Primary citation | Shenoy, R.T.,Sivaraman, J. Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors. J.Struct.Biol., 173:14-19, 2011 Cited by PubMed: 20850545DOI: 10.1016/j.jsb.2010.09.007 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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